ID   UVRC_MYCPN              Reviewed;         586 AA.
AC   P75350;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=MPN_125;
GN   ORFNames=MP029;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; U00089; AAB95677.1; -; Genomic_DNA.
DR   PIR; S73355; S73355.
DR   RefSeq; NP_109813.1; NC_000912.1.
DR   RefSeq; WP_010874482.1; NC_000912.1.
DR   AlphaFoldDB; P75350; -.
DR   SMR; P75350; -.
DR   IntAct; P75350; 1.
DR   STRING; 272634.MPN_125; -.
DR   EnsemblBacteria; AAB95677; AAB95677; MPN_125.
DR   KEGG; mpn:MPN_125; -.
DR   PATRIC; fig|272634.6.peg.132; -.
DR   HOGENOM; CLU_014841_3_2_14; -.
DR   OMA; HIECFDN; -.
DR   BioCyc; MPNE272634:G1GJ3-206-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..586
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138318"
FT   DOMAIN          17..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          201..236
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   586 AA;  67771 MW;  6A495512C3447C81 CRC64;
     MIIVNNTLAF KLKNAPHKPG CYLWKDDAGQ VLYVGKAKDI FKRVHHYFNP NRSFKTRALV
     ERIADVEYVI LKNENDALNL EAKLIKQYKP RFNLVLKENN GYLYFFITAS VKPTLELGRR
     YEFSKNKYFG PFASSKFRLR DIYDLLLKLF PLRKCAPHER GHPCFYYQLK MCMGQCMGED
     TPERYQTTVK GIEQFFNHGP EQVLNHLQQQ EIKASEQQNF EAARHFLDLQ KAVLELVNMQ
     QTAFIKAKQS HDFIGYVFEK NVLAITVFAY VDNQLIGKNQ QVFELPQDDE KEVESALVTF
     IYHYYSTNKI PKTLTVSLSE ENLSLLANSL KINVTQPKNG EQKSILQTVI DNARYALNTK
     WTGFINNLNR AEVHQQLAQL LQVPSIQSLE IIDISFYDKD HVVGAMLRYE NGKRMKALSR
     RYNINIDHKG DTNYMADVVY RRIISSIQTH KQLPLSDLLI VDGGIAQINT VTKVFASFPN
     VTQPIIIGLA KNTRHQTDHI VLTDNTTINI DKNTPLFAYL TTIQEEVDSF AKHNAFKRVS
     RARFQNPLLQ IEGVGRKTVQ ILLDNFQTNA KHWSCFFERI ITVYSC