UVRC_MYCS2
ID UVRC_MYCS2 Reviewed; 706 AA.
AC A0QWV6; I7GAF4;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN OrderedLocusNames=MSMEG_3078, MSMEI_3000;
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT mutations or sequencing errors?";
RL Genome Biol. 8:R20.1-R20.9(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=18955433; DOI=10.1101/gr.081901.108;
RA Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT and a new MS-based protocol.";
RL Genome Res. 19:128-135(2009).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; CP000480; ABK74829.1; -; Genomic_DNA.
DR EMBL; CP001663; AFP39464.1; -; Genomic_DNA.
DR RefSeq; WP_011728800.1; NZ_SIJM01000002.1.
DR RefSeq; YP_887394.1; NC_008596.1.
DR AlphaFoldDB; A0QWV6; -.
DR SMR; A0QWV6; -.
DR STRING; 246196.MSMEI_3000; -.
DR PRIDE; A0QWV6; -.
DR EnsemblBacteria; ABK74829; ABK74829; MSMEG_3078.
DR EnsemblBacteria; AFP39464; AFP39464; MSMEI_3000.
DR GeneID; 66734482; -.
DR KEGG; msg:MSMEI_3000; -.
DR KEGG; msm:MSMEG_3078; -.
DR PATRIC; fig|246196.19.peg.3039; -.
DR eggNOG; COG0322; Bacteria.
DR OMA; HIECFDN; -.
DR OrthoDB; 1036075at2; -.
DR Proteomes; UP000000757; Chromosome.
DR Proteomes; UP000006158; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.340; -; 1.
DR Gene3D; 3.40.1440.10; -; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_HhH_N; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; SSF46600; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF82771; SSF82771; 1.
DR TIGRFAMs; TIGR00194; uvrC; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW Reference proteome; SOS response.
FT CHAIN 1..706
FT /note="UvrABC system protein C"
FT /id="PRO_1000077809"
FT DOMAIN 16..95
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 208..243
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT REGION 651..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 706 AA; 77443 MW; 576F941C487F429E CRC64;
MPDPATYRPA PGSIPVEPGV YRFRDPHGRV IYVGKAKSLR SRLTSYFADI TSLAPRTRQM
VMTAGSVEWT VVTTEVEALQ LEYNWIKEFD PRFNVRYRDD KSYPVLAVTL NEEYPRLMVY
RGPRRKGVRY FGPYSHAWAI RETLDLLTRV FPARTCSAGV FKRHKQIDRP CLLGYIDKCS
APCVGRVSAE QHRQIVLDFC DFLGGKTDRL AKDMEQQMTA AAEQLDFERA ARLRDDISAL
KRALEKQAVV FGDGTDADVV AFADDDLEAA VQVFHVRGGR VRGQRGWIVE KSSEPAATGD
ADLGQSGQEQ LVEQFLTQFY GEQAELGSAS DTGGDEATNP VPRQVLVPVL PPNADELATW
LSGLRGSRVS LRVPVRGDKR ALAETVQRNA QEALAQHKLK RAGDFNARSE ALQSIQEALG
LADAPLRIEC VDISHVQGTD VVASLVVFED GLPRKSDYRH YAIREAAGDG RSDDVASIAE
VTRRRFLRHT SDSQPDPSAE QRPRRFAYPP NLFVVDGGAP QVNAAAAVLE DLGVDDVAVI
GLAKRLEEVW VPSEPDPVIL PRNSEGLYLL QRVRDEAHRF AISYHRSKRS KRMTASALDS
VRGLGEHRRK ALVAHFGSVA RLKEATVDEI TAVPGIGVAT ARAVQEALGV APQNGTAPDP
APGTGDPQTP ADPHSAATAA DIEDDRHATG ATGPQMNGSE QQVDRV
