ID   UVRC_MYCSK              Reviewed;         676 AA.
AC   A1UFN2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Mkms_2442;
OS   Mycobacterium sp. (strain KMS).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; unclassified Mycobacterium.
OX   NCBI_TaxID=189918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KMS;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Mycobacterium sp. KMS.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000518; ABL91640.1; -; Genomic_DNA.
DR   RefSeq; WP_011559792.1; NC_008705.1.
DR   AlphaFoldDB; A1UFN2; -.
DR   SMR; A1UFN2; -.
DR   STRING; 189918.Mkms_2442; -.
DR   EnsemblBacteria; ABL91640; ABL91640; Mkms_2442.
DR   KEGG; mkm:Mkms_2442; -.
DR   HOGENOM; CLU_014841_1_1_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..676
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077811"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   676 AA;  74809 MW;  9C7AA49D126FF01F CRC64;
     MPDPSTYRPA PGSIPVEPGV YRFRDPHGRV IYVGKAKSLR SRLNSYFADL SGLAPRTRQM
     VMTAAKVEWT VVNTEVEALQ LEYNWIKEFD PRFNIRYRDD KSYPVLAVTL NEEFPRLKVY
     RGPRKKGVRY FGPYSHAWAI RETVDLLTRV FPARTCSAGV FKRHNQIDRP CLLGYIDKCS
     APCVGRVSAE QHRQIVLDFC DFLAGKTDRL VRDLERKMTA AAEDLDFERA ARLRDDIGAL
     RRALEKQTVV FGDGTDADVV AFADDDLEAA VQVFHVRGGR VRGQRGWIVE KSGEPGESGE
     GQLVEQFLTQ FYGDQAELGS AGDNAGDSGQ DEATNPVPRQ VLVPCLPDNA DELTEWLSQL
     RGSRVALRVP QRGDKKALFE TVQRNAKEAL AQHKLKRAGD FTARTAALQS IQDTLGLADA
     PLRIECIDIS HVQGTDVVAS LVVFEDGLPR KSDYRHYAIR EAAGDGRSDD VASIAEVTRR
     RFYRHLHDTQ HPTELSAEGK SRKFAYPPNL FVVDGGAPQV NAAQAVLDEL GISDVAVIGL
     AKRLEEVWVP SGSDLGPEPI ILPRNSEGLY LLQRVRDEAH RFAITYHRSK RSKRMTASAL
     DSVRGLGEHR RKALVTHFGS VARLKEASVE EITAVPGIGV TTARAVLEAL GVPQAAPADS
     DTAAAVIDDD QRRVTG