ID   UVRC_MYCTA              Reviewed;         646 AA.
AC   A5U2C2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=MRA_1429;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000611; ABQ73172.1; -; Genomic_DNA.
DR   RefSeq; WP_003407347.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U2C2; -.
DR   SMR; A5U2C2; -.
DR   STRING; 419947.MRA_1429; -.
DR   EnsemblBacteria; ABQ73172; ABQ73172; MRA_1429.
DR   GeneID; 45425398; -.
DR   KEGG; mra:MRA_1429; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_1_1_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..646
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077812"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   646 AA;  71614 MW;  CD7792F6C54E6709 CRC64;
     MPDPATYRPA PGSIPVEPGV YRFRDQHGRV IYVGKAKSLR SRLTSYFADV ASLAPRTRQL
     VTTAAKVEWT VVGTEVEALQ LEYTWIKEFD PRFNVRYRDD KSYPVLAVTL GEEFPRLMVY
     RGPRRKGVRY FGPYSHAWAI RETLDLLTRV FPARTCSAGV FKRHRQIDRP CLLGYIDKCS
     APCIGRVDAA QHRQIVADFC DFLSGKTDRF ARALEQQMNA AAEQLDFERA ARLRDDLSAL
     KRAMEKQAVV LGDGTDADVV AFADDELEAA VQVFHVRGGR VRGQRGWIVE KPGEPGDSGI
     QLVEQFLTQF YGDQAALDDA ADESANPVPR EVLVPCLPSN AEELASWLSG LRGSRVVLRV
     PRRGDKRALA ETVHRNAEDA LQQHKLKRAS DFNARSAALQ SIQDSLGLAD APLRIECVDV
     SHVQGTDVVG SLVVFEDGLP RKSDYRHFGI REAAGQGRSD DVACIAEVTR RRFLRHLRDQ
     SDPDLLSPER KSRRFAYPPN LYVVDGGAPQ VNAASAVIDE LGVTDVAVIG LAKRLEEVWV
     PSEPDPIIMP RNSEGLYLLQ RVRDEAHRFA ITYHRSKRST RMTASALDSV PGLGEHRRKA
     LVTHFGSIAR LKEATVDEIT AVPGIGVATA TAVHDALRPD SSGAAR