ID   UVRC_MYCVP              Reviewed;         678 AA.
AC   A1T8K4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Mvan_2697;
OS   Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 /
OS   KCTC 9966 / NRRL B-24157 / PYR-1) (Mycobacterium vanbaalenii).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=350058;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 /
RC   PYR-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Anderson I.J., Miller C., Richardson P.;
RT   "Complete sequence of Mycobacterium vanbaalenii PYR-1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000511; ABM13504.1; -; Genomic_DNA.
DR   RefSeq; WP_011779912.1; NC_008726.1.
DR   AlphaFoldDB; A1T8K4; -.
DR   SMR; A1T8K4; -.
DR   STRING; 350058.Mvan_2697; -.
DR   PRIDE; A1T8K4; -.
DR   EnsemblBacteria; ABM13504; ABM13504; Mvan_2697.
DR   KEGG; mva:Mvan_2697; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_1_1_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000009159; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..678
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077813"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          477..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   678 AA;  74911 MW;  938D5018E0096007 CRC64;
     MPDPSTYRPA PGSIPVEPGV YRFRDPHGRV IYVGKAKSLR SRLNSYFADL SGLAPRTRQM
     VMTAASVEWT VVSTEVEALQ LEYNWIKEFD PRFNIRYRDD KSYPVLAVTL NEEYPRLKVY
     RGPRRKGVRY FGPYSHAWAI RETLDLLTRV FPARTCSNGV FKRHSQIDRP CLLGYIDKCA
     APCVGRVSAE EHRRIVLDFC DFLAGKTDRL IREMEQQMNA AAEELDFERA ARLRDNIGAM
     RRAMEKQTVV LGDGTDADVV AFADDELEAA VQVFHVRGGR VRGQRGWVIE KSGEPGESTP
     AYLVEQFLTQ FYGDQAELGG AADEATNPVP RQVLVPVLPD TTEELETWLS QLRGSRVSLR
     VPQRGDKRAL AETVKRNAEQ ALTQHKLKRA GDFTARSAAL QSIQEALGLA DAPLRIECVD
     ISHVQGTDVV ASLVVFEDGL PRKSDYRHFA IREAAGDGRS DDVASIAEVT RRRFHRHLRD
     AEAAPEGRPE QGPRASARPE QGPRASARPA RFAYPPNLFV VDGGAPQVNA AAAVLDELGI
     SDVAVIGLAK RLEEVWVPNL DGTAPDPVIF PRNSDGLYLL QRVRDEAHRF AISYHRSKRS
     KRMTASALDS VRGLGEHRRK ALVTHFGSLA RLKQASVDEI TAVPGIGAAT ARAVLEALGA
     DSGAAPTDIG NDQSRISG