ID   UVRC_NATPD              Reviewed;         575 AA.
AC   Q3ITA0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=NP_1086A;
OS   Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM
OS   8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Natronomonas.
OX   NCBI_TaxID=348780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB
RC   2260 / Gabara;
RX   PubMed=16169924; DOI=10.1101/gr.3952905;
RA   Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA   Oesterhelt D.;
RT   "Living with two extremes: conclusions from the genome sequence of
RT   Natronomonas pharaonis.";
RL   Genome Res. 15:1336-1343(2005).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CR936257; CAI48634.1; -; Genomic_DNA.
DR   RefSeq; WP_011322270.1; NC_007426.1.
DR   AlphaFoldDB; Q3ITA0; -.
DR   SMR; Q3ITA0; -.
DR   STRING; 348780.NP_1086A; -.
DR   PRIDE; Q3ITA0; -.
DR   EnsemblBacteria; CAI48634; CAI48634; NP_1086A.
DR   GeneID; 3703459; -.
DR   KEGG; nph:NP_1086A; -.
DR   eggNOG; arCOG00873; Archaea.
DR   eggNOG; arCOG04753; Archaea.
DR   HOGENOM; CLU_014841_3_1_2; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 5341at2157; -.
DR   Proteomes; UP000002698; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..575
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227498"
FT   DOMAIN          15..90
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          198..233
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   575 AA;  63154 MW;  0C2FE3F7F01891CE CRC64;
     MDASAVRKRA AELPAEPGVY QFEAGESVLY VGKAVDLRER VRSYVAPRSD RIRRMVEAAA
     AVDFAVTDTE TQALLLEANL IKRHQPRYNV RLKDDKSYPL VQLTAHEAPR IEITRTPDEA
     ATVFGPYTDK SRVETVVKAL RETYELRGCS DHKYEGRDRP CLDYELGLCS APCTGEIDTD
     AYAEDVESAR RFFDGETGVL AEPLRREMET AAASQAFERA ASLRDRLEAV ETFHEGGSEA
     VSGRGGRRLD VLGVAVEGES ATVARLRSED GKLVERDRHR VDAPADAESV PSVLAAFIPQ
     FYAERSLPDV LLLSERYDDE ELDQWLHAEG VDIRVPGAGR AATLVELALK NARRTTAEAD
     GPTALARRLG IDRPERIEGF DVSHAGGKDA VGSNVVFVDG SPETADYRRR SLDDENDDYA
     NMRRLVRWRA TRAVEGRDDR PTPDLLLIDG GDGQLGAAQD ALAETGWDVP AIALAKADEL
     VVTSDGVADW DDGPALRLLQ RVRDEAHRFA VQYHQQVRDA VSTPLDSVPG VGPELRERLL
     KRFGTVDGVR SASREELERV DGVGEDTAAA IDAAL