ID   UVRC_NEIG1              Reviewed;         617 AA.
AC   Q5F928;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=NGO0578;
OS   Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=242231;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700825 / FA 1090;
RA   Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F.,
RA   Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C.,
RA   Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H., Qi S.,
RA   Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.;
RT   "The complete genome sequence of Neisseria gonorrhoeae.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW89309.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE004969; AAW89309.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_207721.1; NC_002946.2.
DR   AlphaFoldDB; Q5F928; -.
DR   SMR; Q5F928; -.
DR   STRING; 242231.NGO_0578; -.
DR   EnsemblBacteria; AAW89309; AAW89309; NGO_0578.
DR   KEGG; ngo:NGO_0578; -.
DR   PATRIC; fig|242231.10.peg.683; -.
DR   HOGENOM; CLU_014841_3_0_4; -.
DR   Proteomes; UP000000535; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..617
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227449"
FT   DOMAIN          22..100
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          209..244
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   617 AA;  69688 MW;  AC9A7EEFCB68C6DA CRC64;
     MNTENRSPEQ FDIPLFLKNL PKLPGVYRFF DEGGNVLYVG KAVNLKRRVS GYFQKNDHSP
     RIALMVKQVR HIETTITRSE AEALILENNF IKALSPKYNI LFRDDKSYPY LMLSGHQYPQ
     MAYYRGTLKN PNQYFGPYPN SNAVRDSIQV LQKVFMLRTC EDSVFEHRDR PCLLYQIKRC
     TAPCVGHISE EDYCDSVRQA ATFLNGKTDE LTRTLQHKMQ TAAANLQFEE AARYRDQIQA
     LGIIQSNQFI DSKNPNNPND IDLLALAVSD GLVCVHWVSI RGGRHVGDKS FFPDTKNDPE
     PNGQDYAEAF VAQHYLGKSK PDIIISNFPV PDALKEALEG EHGKQMQFVT KTIGERKVWL
     KMAEQNAQMA ITQRHLQQSN QQHRIDELAK ILGMNSDGIN RLECFDISHT QGEATIASCV
     VYDEQNIQPS QYRRYNITTA KPGDDYAAMR EVLTRRYGKI QEAEANGESV KWPDVVLIDG
     GKGQIGVAVS VWEELGLHIP LVGIAKGPER KAGMEELILP FTGELFRLPP NSPALHLLQT
     VRDESHRFAI TGHRKKRDKA RVTSSLGDIP GVGSKRRQAL LTRFGGLRGV IAASREDLEK
     VEGISKALAE TIYNHLH