ID   UVRC_NEIMB              Reviewed;         617 AA.
AC   Q9JZ26;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=NMB1326;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE002098; AAF41701.1; -; Genomic_DNA.
DR   PIR; A81095; A81095.
DR   RefSeq; NP_274345.1; NC_003112.2.
DR   AlphaFoldDB; Q9JZ26; -.
DR   SMR; Q9JZ26; -.
DR   STRING; 122586.NMB1326; -.
DR   PaxDb; Q9JZ26; -.
DR   EnsemblBacteria; AAF41701; AAF41701; NMB1326.
DR   KEGG; nme:NMB1326; -.
DR   PATRIC; fig|122586.8.peg.1663; -.
DR   HOGENOM; CLU_014841_3_0_4; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..617
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138323"
FT   DOMAIN          22..100
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          209..244
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   617 AA;  69822 MW;  D2C4B27DF44113AF CRC64;
     MNKETRFPEH FDIPLFLKNL PNLPGVYRFF NESGNVLYVG KAVNLKRRVS GYFQKNDHSP
     RIALMVKQVH HIETTITRSE SEALILENNF IKALSPKYNI LFRDDKSYPY LMLSGHQYPQ
     MAYYRGTLKK PNQYFGPYPN SNAVRDSIQV LQKVFMLRTC EDSVFEHRDR PCLLYQIKRC
     TAPCVGHISE EDYRDSVREA ATFLNGKTDE LTRTLQHKMQ TAAANLQFEE AARYRDQIQA
     LGIMQSNQFI DSKNPNNPND IDLLALAVSD GLVCVHWVSI RGGRHVGDKS FFPDTKNDPE
     PNGQDYAEAF VAQHYLGKSK PDIIISNFPV PDALKEALEG EHGKQMQFVT KTIGERKVRL
     KMAEQNAQMA IAQRRLQQSS QQHRIDELAK ILGMDSDGLN RLECFDISHT QGEATIASCV
     VYDEQNIQPS QYRRYNITTA KPGDDYAAMR EVLTRRYGKM QEAEANGETV KWPDAVLIDG
     GKGQIGVAVS VWEELGLHIP LVGIAKGPER KAGMEELILP FTGEVFRLPP NSPALHLLQT
     VRDESHRFAI TGHRKKRDKA RVTSSLSDIP GVGSKRRQAL LTRFGGLRGV IAASREDLEK
     VEGISKALAE TIYNHLH