ID   UVRC_NOCFA              Reviewed;         673 AA.
AC   Q5YTP9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=NFA_35940;
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=247156;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AP006618; BAD58442.1; -; Genomic_DNA.
DR   RefSeq; WP_011210127.1; NC_006361.1.
DR   AlphaFoldDB; Q5YTP9; -.
DR   SMR; Q5YTP9; -.
DR   STRING; 247156.NFA_35940; -.
DR   PRIDE; Q5YTP9; -.
DR   EnsemblBacteria; BAD58442; BAD58442; NFA_35940.
DR   GeneID; 61134290; -.
DR   KEGG; nfa:NFA_35940; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_11; -.
DR   OMA; HIECFDN; -.
DR   BioCyc; NFAR247156:NFA_RS17940-MON; -.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..673
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227452"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          488..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   673 AA;  74662 MW;  BB34C789476B41D3 CRC64;
     MADPATYRPA PGTIPVEPGV YKFRDSYGRV IYVGKAKSLR SRLNSYFADV ASLHPRTKQM
     VTTAASVEWT VVSTEVEALQ LEYNWIKEFD PRFNVRYRDD KSYPVLAVTL NEEYPRLFVY
     RGARKKGVRY FGPYAHAWAI RETLDLLLRV FPARTCSTGV FKRHNQIGRP CLLGYIDKCS
     APCVGRVSAE EHRAIVEDFC DFLAGRTDKM VRELERRMHA AAEDLDFETA ARLRDDVQAL
     RRALEKQAVV LGTGTDADVI AFATDELEVA VQIFHVRDGR VRGQRGWVVD KSGDAVDSGT
     GDDETGALVE QFLTQFYGEQ VAYADQTPDE QPATVVPREV LVPQLPAGHE QLQEWLSRLR
     GSAVRLRVPQ RGDKKALAET VERNAKEALA QHKLKRAGDL TSRSAALQDI QDALDLDSAP
     LRIECVDISH VQGTDVVASL VVFEDGLPRK SDYRHYAIKE AAGEGRSDDV GSIAEVTRRR
     FYRLRKERDE AERDELDGTA AGAPLVDDDE TPTSRPGIDP TTGRPRKFAY PPNLYVVDGG
     APQVAAAAEV LDELGITDVA VIGLAKRLEE VWVPGEPDPV ILPRNSEALF LLQRVRDEAH
     RFAITFHRSK RSRRMTASAL DSVRGLGAAR RTALVTHFGS VAKLKEATVE EITEVPGIGV
     ATAKAVLAAL HQE