ID   UVRC_NOSS1              Reviewed;         627 AA.
AC   Q8YTI9;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=alr2728;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; BA000019; BAB74427.1; -; Genomic_DNA.
DR   PIR; AI2146; AI2146.
DR   RefSeq; WP_010996881.1; NZ_RSCN01000030.1.
DR   AlphaFoldDB; Q8YTI9; -.
DR   SMR; Q8YTI9; -.
DR   STRING; 103690.17131821; -.
DR   EnsemblBacteria; BAB74427; BAB74427; BAB74427.
DR   KEGG; ana:alr2728; -.
DR   eggNOG; COG0322; Bacteria.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..627
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138285"
FT   DOMAIN          26..105
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          215..250
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   627 AA;  71697 MW;  4CD147E810772D4B CRC64;
     MTTSAQILPL VKDPERLEAR LSEIPPEPGV YFMRDGSDRI IYIGKSRKLR SRVRSYFREG
     YNKTERIATM AKLVTEIEFI VTDTEAEALA LEANLIKQHQ PYFNVLLKDD KKYPYVCITW
     SEDYPRIFIT RKRQLGKEKD KYYGPYTDSG LLREILRISK RIFALRQRPQ PLFKDRPCLN
     YDLGRCPGVC QQLISPEEYR KTVQKVAMVF QGRTQELIDI LSEQMEKAAE ALNFEVAARI
     RDQIAGLKSL TAEQKVSLPD DTVSRDAIAL AGDAQHACIQ LFQIRAGQLV GRLAFVAESH
     AEPGAILQRV LEEHYQTAES VEIPAEILVQ HELPDAEILA DVLTQLKGRK VTIFTPQRQV
     KAELIEMVER NAQYELQRMQ KLGDRNHQAT QDLAAILDLP NLPHRIEGYD ISHIQGSNAV
     ASQVVFIDGL PAKQNYRHYK IKNPTVTIGH SDDFASLAEV IQRRFRKYAE DPQLSRVGNP
     DWPDLIMIDG GKGQLSSVVT VLQEMNLLED LRVISLAKRR EEIFLPGESQ PLKTDAEQPG
     VQLLRRLRDE AHRFAVSFHR QQRSDKLKRS RLDEIPGLGH HRQKQMLAHF RSVDYIRQAT
     PSQIAEVPGI GPHLAQAIYD YFHPSHL