ID   UVRC_PARMW              Reviewed;         652 AA.
AC   Q7U6U0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=SYNW1246;
OS   Parasynechococcus marenigrum (strain WH8102).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Parasynechococcus; Parasynechococcus marenigrum.
OX   NCBI_TaxID=84588;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH8102;
RX   PubMed=12917641; DOI=10.1038/nature01943;
RA   Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P.,
RA   Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T.,
RA   Dufresne A., Partensky F., Webb E.A., Waterbury J.;
RT   "The genome of a motile marine Synechococcus.";
RL   Nature 424:1037-1042(2003).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; BX569692; CAE07761.1; -; Genomic_DNA.
DR   RefSeq; WP_011128110.1; NC_005070.1.
DR   AlphaFoldDB; Q7U6U0; -.
DR   SMR; Q7U6U0; -.
DR   STRING; 84588.SYNW1246; -.
DR   EnsemblBacteria; CAE07761; CAE07761; SYNW1246.
DR   KEGG; syw:SYNW1246; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_3; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000001422; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..652
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227485"
FT   DOMAIN          20..99
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          209..244
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   652 AA;  74609 MW;  7AB268C643FFC5BD CRC64;
     MPPLLTQPEV LERRLKEIPP EPGCYLMRDG EDRILYVGKS KSLRSRVRSY FRSRHDLSPR
     IRLMTRQVCE IEFIVTDSEA EALALESNLI KNHQPHFNVL LKDDKKYPYL CITWSEAYPR
     IFITRRRRFR SPLDRFYGPY VDVGLLRRTL FLVKRVFPLR QRPRPLHPDR TCLNYSIGRC
     PGVCQEKITS EDYHRTLRKV AMVFQGRSDE LQRLLDEQMN RYAERLDFES AARVRDQLQG
     LDQLTADQKM SLPDSSVSRD VLALACDDRL AAVQLFQMRA GKLVGRLGYT ADASALAPGL
     ILQRVIEEHY SQVDAVEVPP ELLVQHALPQ QQLLEDWLTE QRERKVQIHC PKQRQKADLI
     ELVQRNAEFE LLRAKQGQEQ QALATEDLAQ LLEMPTPPRR IEGYDISHIQ GSDAVASQVV
     FIDGLPAKQH YRKYKIRSSS IQSGHSDDFM AMAEIMRRRF RRWARAKADG VDVGALRHKG
     GSALQTDGLN DWPDVVMIDG GKGQLSAVME ALRELDLHED LNVCSLAKQR EEVFLPGESQ
     PLESEPDQLG VALLRRLRDE AHRFAVSFHR QQRGERMKRS RLSDIPGVGP KRVKDLLAHF
     HSIDAIQMAS VDLLSKAPGV GTALARDIHG FFHPAEEAGQ DECSEEPRAH TA