ID   UVRC_PARXL              Reviewed;         734 AA.
AC   Q13VN8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Bxeno_A3313;
GN   ORFNames=Bxe_A1095;
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400;
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA   Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA   Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA   Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT   shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABE31851.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000270; ABE31851.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_038457504.1; NZ_CP008760.1.
DR   AlphaFoldDB; Q13VN8; -.
DR   SMR; Q13VN8; -.
DR   STRING; 266265.Bxe_A1095; -.
DR   EnsemblBacteria; ABE31851; ABE31851; Bxe_A1095.
DR   KEGG; bxb:DR64_3258; -.
DR   KEGG; bxe:Bxe_A1095; -.
DR   PATRIC; fig|266265.5.peg.3476; -.
DR   eggNOG; COG0322; Bacteria.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..734
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264881"
FT   DOMAIN          21..99
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          345..386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..369
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   734 AA;  80270 MW;  C5229B1173532B44 CRC64;
     MTEPEATDVF EPKKVLTQLP HLPGVYRYYD THGAVLYVGK ARDLKKRVSS YFTKTQLSPR
     IAMMVTRIAR VETTVTRSEA EALLLENNLI KALAPRYNIL FRDDKSYPYL KLTGHKFPRM
     AYYRGAVDRK NQYFGPFPSA WAVRESIQIL QRVFQLRTCE DSVFNNRTRP CLLHQIGRCT
     APCVAAISEE DYARDVANAS RFLLGRQGEV MSELEQKMHA FASELKFEQA AAVRNQMSSL
     STVLHQQAIE VGSDSDVDIL AVVALGGRVC VNLAMVRGGR HLGDKAYFPA HVESALTVDE
     GGLEDGDERL ADAATGPVSL AEEEVGGEAE PADTADALAI ARDMPPEDEQ DEDEDEDEQD
     GEPEEAGSGA DSDSDSAKPR KGRATGGIES EVLEAFIAQH YLGNRVPPVL VVSHAPATRE
     LVDVLIEQAG HKVTVLRQPQ GQRRAWLVMA EQNARLALAR LLSEQGSQQA RTRALTDTLG
     MECDDLAHLR IECFDISHTM GEATQASCVV YHHHKMQSSE YRRYNITGIT PGDDYAAMRQ
     VLTRRYEKMV AQAAANAADE AAELQSDAAA DPSLAPDAAE PVAAGGVLPT IVLIDGGKGQ
     VEIARQVFTE LGLDTGMLVG VAKGEGRKVG LETLIFADGR APLELGKESA ALMLVAQIRD
     EAHRFAITGM RAKRGKTRQT SRLEELEGVG AKRRQRLLAR FGGLRGVVAA SVEDLASVEG
     ISQALAEQIY RQLH