ID   UVRC_PASMU              Reviewed;         608 AA.
AC   P57882;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=PM0857;
OS   Pasteurella multocida (strain Pm70).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=272843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pm70;
RX   PubMed=11248100; DOI=10.1073/pnas.051634598;
RA   May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT   "Complete genomic sequence of Pasteurella multocida Pm70.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK02941.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE004439; AAK02941.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_032854373.1; NC_002663.1.
DR   AlphaFoldDB; P57882; -.
DR   SMR; P57882; -.
DR   STRING; 747.DR93_1698; -.
DR   PRIDE; P57882; -.
DR   EnsemblBacteria; AAK02941; AAK02941; PM0857.
DR   KEGG; pmu:PM0857; -.
DR   PATRIC; fig|272843.6.peg.867; -.
DR   HOGENOM; CLU_014841_3_2_6; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000809; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..608
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138325"
FT   DOMAIN          13..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          201..236
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   608 AA;  68946 MW;  A021B63EB460E77A CRC64;
     MFDAKSFLAN VSHDAGVYRM YDEKDTVIYV GKAKDLKKRL SSYFRTHLSS KKTEALVSAI
     ARIDTTITSS ETEALLLEHN YIKTYQPRYN VLLRDDKSYP YILLTAERHP RISAYRGSKK
     IKGEYFGPYP HASAVRETLS LLQKLFPIRQ CENAVYNNRS RPCLQYQIGR CAAPCVAGYV
     TDEAYLQQVE LARLFLQGKD QQVLEHLIHK MEQASLALDF EEAARIRDQI QAVRAVMEKQ
     FVSTERLDDM DILSIAYQLG IACVQVLFIR QGKMLGNRSY FPKVPANTTL SELTATFVGQ
     FYLQAHQGRS IPHRIIVDHK LSEKTELEEL LTQQAGRKVH IQDNTKGEKS KYLQLAKMNA
     QSALVTQLKQ STLLKERYQA LQAILQLGEI RRMECFDISH TMGEQTIASC VVFNQDGPLK
     SDYRRFNITG ITAGDDYAAM EQALLKRYDK PLEQEKIPDV IFIDGGKGQL NRALQTFSKL
     NVKWDKNQPH LIGVAKGIDR KAGLETLILS KQGKILHLPS DHLALHLIQH IRDESHQHAI
     SGHRKKRQQA FLQSGLESVE GVGAKRRQTL LKYLGGMQGV KKATLDEIAS VPGISKALAE
     RIYDALRD