ID   CAF1R_YERPE             Reviewed;         301 AA.
AC   P26950; Q9R376;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 2.
DT   25-MAY-2022, entry version 149.
DE   RecName: Full=F1 operon positive regulatory protein;
GN   Name=caf1R; OrderedLocusNames=YPMT1.81c, Y1097, YP_pMT085;
OS   Yersinia pestis.
OG   Plasmid pMT1 (pMT-1), and Plasmid pFra.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pFra;
RX   PubMed=1677900; DOI=10.1016/0014-5793(91)80945-y;
RA   Galyov E.E., Karlishev A.V., Chernovskaya T.V., Dolgikh D.A., Smirnov O.Y.,
RA   Volkovoy K.I., Abramov V.M., Zav'Yalov V.P.;
RT   "Expression of the envelope antigen F1 of Yersinia pestis is mediated by
RT   the product of caf1M gene having homology with the chaperone protein PapD
RT   of Escherichia coli.";
RL   FEBS Lett. 286:79-82(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pFra;
RX   PubMed=1633857; DOI=10.1016/0014-5793(92)80650-6;
RA   Karlyshev A.V., Galyov E.E., Abramov V.M., Zav'Yalov V.P.;
RT   "Caf1R gene and its role in the regulation of capsule formation of Y.
RT   pestis.";
RL   FEBS Lett. 305:37-40(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis; PLASMID=pMT1 (pMT-1);
RX   PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA   Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA   Brubaker R.R., Garcia E.;
RT   "Structural organization of virulence-associated plasmids of Yersinia
RT   pestis.";
RL   J. Bacteriol. 180:5192-5202(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis; PLASMID=pMT1 (pMT-1);
RX   PubMed=9826348; DOI=10.1128/iai.66.12.5731-5742.1998;
RA   Lindler L.E., Plano G.V., Burland V., Mayhew G.F., Blattner F.R.;
RT   "Complete DNA sequence and detailed analysis of the Yersinia pestis KIM5
RT   plasmid encoding murine toxin and capsular antigen.";
RL   Infect. Immun. 66:5731-5742(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis; PLASMID=pMT1 (pMT-1);
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis; PLASMID=pMT1 (pMT-1);
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Positive regulator of F1 operon expression.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC82755.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAS58717.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAB55263.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X61996; CAA43969.1; -; Genomic_DNA.
DR   EMBL; AF074611; AAC82755.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AF053947; AAC13221.1; -; Genomic_DNA.
DR   EMBL; AL117211; CAB55263.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017045; AAS58717.1; ALT_INIT; Genomic_DNA.
DR   PIR; S19097; S19097.
DR   PIR; T14705; T14705.
DR   PIR; T15012; T15012.
DR   RefSeq; NP_395427.1; NC_003134.1.
DR   RefSeq; NP_857695.1; NC_004835.1.
DR   RefSeq; WP_002211761.1; NZ_WUCM01000058.1.
DR   AlphaFoldDB; P26950; -.
DR   SMR; P26950; -.
DR   DNASU; 1149241; -.
DR   EnsemblBacteria; AAC82755; AAC82755; AAC82755.
DR   EnsemblBacteria; AAS58717; AAS58717; YP_pMT085.
DR   GeneID; 57977633; -.
DR   KEGG; ype:YPMT1.81c; -.
DR   KEGG; ypk:caf1R.pl; -.
DR   KEGG; ypm:YP_pMT085; -.
DR   PATRIC; fig|214092.21.peg.209; -.
DR   HOGENOM; CLU_000445_81_1_6; -.
DR   PRO; PR:P26950; -.
DR   Proteomes; UP000000815; Plasmid pMT1 (pMT-1).
DR   Proteomes; UP000001019; Plasmid pMT1.
DR   Proteomes; UP000002490; Plasmid pMT-1.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 3.20.80.10; -; 1.
DR   InterPro; IPR029442; GyrI-like.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR011256; Reg_factor_effector_dom_sf.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF06445; GyrI-like; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF55136; SSF55136; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Plasmid; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..301
FT                   /note="F1 operon positive regulatory protein"
FT                   /id="PRO_0000194505"
FT   DOMAIN          8..107
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        26..47
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        74..97
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   CONFLICT        124
FT                   /note="E -> V (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        135
FT                   /note="E -> V (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   301 AA;  36054 MW;  E1EB5AD5C4CD43C0 CRC64;
     MLKQMTVNSI IQYIEENLES KFINIDCLVL YSGFSRRYLQ ISFKEYVGMP IGTYIRVRRA
     SRAAALLRLT RLTIIEISAK LFYDSQQTFT REFKKIFGYT PRQYRMIPFW SFKGLLGRRE
     INCEYLQPRI CYLKERNIIG QCFNFRDLVF YSGIDSKCRL GKLYDSLKKN TAITVSNRIP
     FHDKTNDIIA RTVVWDRNKH FSDSEIKVDK GLYAYFFFND TYDQYVHHMY NIYYNSLPIY
     NLNKRDGYDV EVIKRRNDNT IDCHYFLPIY CDDMEFYNEM QVYHNNIVKP EMSVTLGLPK
     S