ID   UVRC_POLSJ              Reviewed;         666 AA.
AC   Q128Q7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Bpro_3071;
OS   Polaromonas sp. (strain JS666 / ATCC BAA-500).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Polaromonas; unclassified Polaromonas.
OX   NCBI_TaxID=296591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JS666 / ATCC BAA-500;
RX   PubMed=18723656; DOI=10.1128/aem.00197-08;
RA   Mattes T.E., Alexander A.K., Richardson P.M., Munk A.C., Han C.S.,
RA   Stothard P., Coleman N.V.;
RT   "The genome of Polaromonas sp. strain JS666: insights into the evolution of
RT   a hydrocarbon- and xenobiotic-degrading bacterium, and features of
RT   relevance to biotechnology.";
RL   Appl. Environ. Microbiol. 74:6405-6416(2008).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000316; ABE44985.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q128Q7; -.
DR   SMR; Q128Q7; -.
DR   STRING; 296591.Bpro_3071; -.
DR   PRIDE; Q128Q7; -.
DR   EnsemblBacteria; ABE44985; ABE44985; Bpro_3071.
DR   KEGG; pol:Bpro_3071; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_4; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001983; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..666
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264922"
FT   DOMAIN          22..100
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          221..256
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   666 AA;  73153 MW;  038417565A463A9B CRC64;
     MPQNMTASHT PELLAEVAAL PAMPGVYRYF DAEGGVLYVG KARNLKKRVS SYFQKNHGAT
     RIGHMVTKIV RMETTVVRSE AEALLLENNL IKTLNPKYNI LFRDDKSYPY LKLTAVQPSE
     AGSAPVATAF PRIAYYRGAV EKKHRYFGPY PSAWAVKDTM LLLQKVFRLR TCEDTVFNNR
     TRPCLLYQIK RCSAPCVGHV SPEQYALDTA NAERFLQGQT QEILTELERK MLAHADRLEF
     EQAAELRNQM SALSKVLHQQ SMEIGGDKDV DILAVKVQGG KACVNLAMVR GGRHLGDRPY
     FPTHVENATD VAALDAQADE GAGGGGPESD DRAGKTVVPL PARPAKSLEA LVLEAFIAQH
     YIDVPVPPTL VCSEPVDKDL ISALAAQTGS KITAIHQPRE QRRIWLDMAQ KNAALQLARL
     LAEQGSQQAR TRALAEALDL SLDNLDALRI ECFDISHTAG ESTQASCVVF QGHKMQNSEY
     RRYNIEGITP GDDYAAMRQV LTRRYTKLAE AARNGNARLP DLVLVDGGKG QVSMAREVFV
     ELGLDLGLIA GVEKGEGRKV GLEELVFADG REKVYLGRDS AALMLIAQIR DEAHRFAITG
     MRARRAKVRV GGSKLEDIAG IGPKRRASLL QRFGGIRGIA SASAEDIATV DGISKDLAEE
     IYRALH