ID   UVRC_PROM1              Reviewed;         640 AA.
AC   A2C249;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=NATL1_10011;
OS   Prochlorococcus marinus (strain NATL1A).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167555;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NATL1A;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000553; ABM75559.1; -; Genomic_DNA.
DR   RefSeq; WP_011823684.1; NC_008819.1.
DR   AlphaFoldDB; A2C249; -.
DR   SMR; A2C249; -.
DR   STRING; 167555.NATL1_10011; -.
DR   EnsemblBacteria; ABM75559; ABM75559; NATL1_10011.
DR   KEGG; pme:NATL1_10011; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_3; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000002592; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..640
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077817"
FT   DOMAIN          22..101
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          211..246
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   640 AA;  74220 MW;  49E165BEE987A249 CRC64;
     MELIPLIRDK SRLSDFLKDI PNDPGCYLMK DGEDRLLYVG KSKKLRNRVR SYFRSGNELS
     PRISLMVRQV ADIELIVTDN ESEALTLESN LIKSHQPYFN VLLKDDKKYP YVCITWGDKY
     PRIFLTRKRR QRQLKDKYYG PYVDVYLLRK TLFSIKKLFP LRQRRIPLYK DRTCLNYSIG
     RCPGVCQEEI SSEDYKNTLK RVEMIFQGRT DELRILLEKQ MISFSESLKF EEAGSVRDQL
     KGIDRLYESQ KMIIPDSSVC RDIIAMASEE NISSVQIFQM RSGKLIGRLG YFSDNSNFNS
     SQILQQVIEN HYSNVDPVEI PSEILVQHQL VNNILISDWL SEIKKQKVNI NVPKRSRKAE
     IIKLVEKNAN LELQRIKQSH DKNLVELDDL TNILDLENIP KRIECYDISH IQGSDAVASQ
     VVFIDGIAAR QHYRRYKIKS PNIKIGHSDD FESMAEVITR RFRRWARFKE EGGDINALLS
     NQSSVLDNLN LNDWPDLVVI DGGKGQLSSV VAALEELKLD QNLNVISLAK KKEEVFIPNV
     KQSLVTESNQ PGMLLLRRLR DEAHRFAITF HRQKRSQRMK RSQLNEIPGL GPQRIKLLLE
     HFRSIEAIQM ATFSELSSTP GLGRSTAVVI RNYFHPDKNK