ID   UVRC_PROM4              Reviewed;         647 AA.
AC   A9BAF1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=P9211_08821;
OS   Prochlorococcus marinus (strain MIT 9211).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=93059;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9211;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000878; ABX08813.1; -; Genomic_DNA.
DR   RefSeq; WP_012195435.1; NC_009976.1.
DR   AlphaFoldDB; A9BAF1; -.
DR   SMR; A9BAF1; -.
DR   STRING; 93059.P9211_08821; -.
DR   EnsemblBacteria; ABX08813; ABX08813; P9211_08821.
DR   KEGG; pmj:P9211_08821; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_3; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000788; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..647
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000099508"
FT   DOMAIN          26..106
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          216..251
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   647 AA;  74846 MW;  A29ADC07DD9BB546 CRC64;
     MPIIESSQSL LLDKDKLKRI LLTIPSEPGC YLMRDKNETL LYIGKSKSLK SRVRSYFNTN
     NTALSPRISL MVRQVYDIEF ILTDSDSEAL NLESNLIKEH QPYFNILLKD DKKYPYLCIT
     WSEEYPRIFI TRRRRLRNSE DRYYGPYVDV TLLRKTLFLL KKLFPLRQRP RALYKDRTCL
     NYSINRCPGV CQRLIEPDDY HKTLKKVAMI FEGRTDQLKD LLHKQMLIQS KLQEFEKAAI
     IRDQIKGIEQ LYAAQKMTIP DSTVSRDVLG LSIDSNVCCV QLFQMRAGKL VGRIGFVYNS
     LELRSELILQ KVLEEYYSQI DNVTIPPEIL LQSSIPQQSY FEQWLSELRG SQVKIVIPKR
     KEKAELVKLV KRNADIELER VKDGQSKHLI ELEDLTQVLD LAFVPRRIEG YDISHLAGTE
     VVGSQVVFIE GIPAKQHYRK YAIKSSSISS GHSDDYMALA EVIRRRFRRW SKYKADGLDL
     TELRNKKLSS LDPLIITDWP DLIMIDGGKG QLKAVEEALR QLGLDSDINV CSLAKRNEEI
     FVPGSYNKLD TEKNQPGLLL LRRLRDEAHR FAINFHRKKR SLSMKRSQLI DIPGVGPRRI
     KSLLAHFKSV QAIQLATEKE IASVEGLGTE TASIIFKYFN PIERDIV