ID   UVRC_PROM9              Reviewed;         652 AA.
AC   Q31AW7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN   OrderedLocusNames=PMT9312_0918;
OS   Prochlorococcus marinus (strain MIT 9312).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=74546;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9312;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of Prochlorococcus marinus str. MIT 9312.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000111; ABB49978.1; -; Genomic_DNA.
DR   RefSeq; WP_011376472.1; NC_007577.1.
DR   AlphaFoldDB; Q31AW7; -.
DR   SMR; Q31AW7; -.
DR   STRING; 74546.PMT9312_0918; -.
DR   PRIDE; Q31AW7; -.
DR   EnsemblBacteria; ABB49978; ABB49978; PMT9312_0918.
DR   KEGG; pmi:PMT9312_0918; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_3; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000002715; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..652
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264923"
FT   DOMAIN          37..116
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          226..261
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   652 AA;  75997 MW;  6830118C183E4CD9 CRC64;
     MSNSSIEKID NKYNFKIEYK LINNKELLKS RLSEIPKSSG CYLFKDIDNN LLYIGKSKKL
     RSRVSSYFNN YSDLTPRLSL MVRQITEIEI IVTDSEYEAL NLESNLIKTN KPYFNILLKD
     DKKYPYLCIT WSEKYPRIFI TRRRRNRNNL DRYYGPYVDV GLLRRTLFTI KKIFPLRQRP
     RPVYKDRTCL NYSIGRCPGV CQEVISSDDY KKIMQQVSMI FQGRNDDLEI FLQKKMLQFS
     NDLDYENAAK IRDQISGLKL LTESQKISIP DSSINRDIFG IVSEKNVASI QIFQMRSGKL
     IGRIGYSQKL NNEDENHILQ KILEEHYMNV EAVEIPSEIL IQYNLPKQAT IEDWLTELRK
     KKVKILIPKR NKKHETVEMV LKNAKLELDR ILNGIQDNES SIEDLAQILE LSEQPKRIEG
     YDISHIQGSD PVASQVVFID GIPSKQHYRK YKIKDPNVFV GHSDDFASIY EVIHRRFKKW
     SRFKKSGGDF SILNDKTNSK LDNELLSDWP DLIMIDGGKG QLNAAIKALN ELNLEEEVTI
     CSLAKKNEEI FIPGFTKSLD TDENQKGVLL LRRVRDEAHR FALSFHRDKR SKRMNRSQLS
     QISGLGPSRI RELLEYFKSI DAIRIASKED LSKVKGLGKN SVNDIYEYFN EL