ID   UVRC_PROMA              Reviewed;         640 AA.
AC   Q7VBY8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Pro_0954;
OS   Prochlorococcus marinus (strain SARG / CCMP1375 / SS120).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167539;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SARG / CCMP1375 / SS120;
RX   PubMed=12917486; DOI=10.1073/pnas.1733211100;
RA   Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M.,
RA   Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S.,
RA   Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J.,
RA   Tandeau de Marsac N., Weissenbach J., Wincker P., Wolf Y.I., Hess W.R.;
RT   "Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a
RT   nearly minimal oxyphototrophic genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE017126; AAP99998.1; -; Genomic_DNA.
DR   RefSeq; NP_875346.1; NC_005042.1.
DR   RefSeq; WP_011125106.1; NC_005042.1.
DR   AlphaFoldDB; Q7VBY8; -.
DR   SMR; Q7VBY8; -.
DR   STRING; 167539.Pro_0954; -.
DR   PRIDE; Q7VBY8; -.
DR   EnsemblBacteria; AAP99998; AAP99998; Pro_0954.
DR   GeneID; 54200297; -.
DR   KEGG; pma:Pro_0954; -.
DR   PATRIC; fig|167539.5.peg.1003; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_3; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000001420; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..640
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227459"
FT   DOMAIN          26..105
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          215..250
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   640 AA;  73799 MW;  D3ED93A183D5B234 CRC64;
     MRSLNDNLPL ILDPTRLKTT LDNIPKAPGC YLMKDNEDNI IYIGKSINLN SRVKSYFRRR
     NDNNPKNSLM LKQVSLIDFI VTDNELEALN LESNLIKSNQ PHYNILLKDD KKYPYLCITW
     SEDYPRILIV RRRRNRADKD RYYGPYVDVT SLRNTLFLIK KIFPLRQRQR PLYKDKTCLN
     YSIGRCPGVC QKIISSSDYR TVIKKVEMII QGRTSELKKL LEEKMHIYSK EMKYEEALKI
     KNQLSGLNTF SQTQKITEPD SSINRDVIAH ASNDSNTSIQ LFQIRAGKLI ARLAFTADSI
     KTNKENIIQK VIEEHYSQLD PVVIPKEILL DNQIEKIEVI SEWLSEMKGS KVNIKIPKIS
     KKANMVSLVK KNAELELTKL SKGVEKANLA LEELAELLDL PFKPRRIEGY DISHIQGSDA
     VGSQVVFVEG MPAKHHYRKF IIKDETIKLG HSDDYLSIYE LITRRFSRWS KYKEKGVNLS
     DIRNYKSSIL DPSTLADFPD LVMIDGGKGQ LNIALKALEK LNLSEDIKLC SLAKKNEDIF
     IPGNNKPLKC NNDDNGLLLL RRLRDEAHRF AVTFHRKRRT LGMRRTELTE IPGIGPKRIK
     ALLLHFNSVQ AIKMARKEEI ASAPGVGREL AEHIWNYFNK