ID   UVRC_PROMM              Reviewed;         667 AA.
AC   Q7V7L7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=PMT_0724;
OS   Prochlorococcus marinus (strain MIT 9313).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=74547;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9313;
RX   PubMed=12917642; DOI=10.1038/nature01947;
RA   Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A.,
RA   Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L.,
RA   Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C.,
RA   Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R.,
RA   Chisholm S.W.;
RT   "Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche
RT   differentiation.";
RL   Nature 424:1042-1047(2003).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; BX548175; CAE20899.1; -; Genomic_DNA.
DR   RefSeq; WP_011130102.1; NC_005071.1.
DR   AlphaFoldDB; Q7V7L7; -.
DR   SMR; Q7V7L7; -.
DR   STRING; 74547.PMT_0724; -.
DR   EnsemblBacteria; CAE20899; CAE20899; PMT_0724.
DR   KEGG; pmt:PMT_0724; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_3; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000001423; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..667
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264924"
FT   DOMAIN          43..122
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          232..267
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   667 AA;  76661 MW;  D4209DE8830349A7 CRC64;
     MRLTSLQRVG HTAVENNLSN ASQRTILLKD ENRLEQRLKE IPAEPGCYLM RDVEDRLLYV
     GKSKCLRNRV RSYFRSSSDH GPRIRLMVRQ IAEIEFIVTD SEAESLVLES NLIKNQQPHF
     NVLLKDDKKY PYLCITWSEE YPRIFITRRR RFRNKNDRFY GPYVDVGLLR RTLLLVKRSF
     PLRQRPRPLH QDRTCLNYSI GRCPGVCQQK ITPQDYHQVL RKVAMVFQGR NQELKVLLEK
     QMERYSDRMD YESAANIRDQ IKGLEQLTEG QKMSLPDSSV SRDVLAIASD HRVAAVQLFQ
     MRAGKLVNRL GFTADAVDQT LGSVLQRVIE EHYSQVDAVE VPPEVLVQYS LPQQELLVDW
     LSEHRGRRVQ ISCPQRQAKA ELIELVERNA VFELSRAKSG QQQQELATED LAQLLELTTQ
     PRRIEGYDIS HIQGSDAVAS QVVFIDGLPA KQHYRKYKIK SSSIKSGHSD DFMAMAEIMR
     RRFRRWARVK QEGSNFENLQ RCSGSALQTD GLNDWPDVVM IDGGKGQLSS AMEALRELDL
     HEDLVVCSLA KKHEQIFVPG QSKPLDSDPD QLGVVLLRRL RDEAHRFAVS YHRQQRGVRM
     NRSRLTDIPG LGPRRVRDLL AHFQSIDAIQ LASVQQISQA PGLGPALALQ VWTYFHPEAD
     IALEEVA