ID   UVRC_PROMT              Reviewed;         640 AA.
AC   Q46L08;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=PMN2A_0328;
OS   Prochlorococcus marinus (strain NATL2A).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NATL2A;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000095; AAZ57820.1; -; Genomic_DNA.
DR   RefSeq; WP_011293862.1; NC_007335.2.
DR   AlphaFoldDB; Q46L08; -.
DR   SMR; Q46L08; -.
DR   STRING; 59920.PMN2A_0328; -.
DR   EnsemblBacteria; AAZ57820; AAZ57820; PMN2A_0328.
DR   KEGG; pmn:PMN2A_0328; -.
DR   HOGENOM; CLU_014841_3_2_3; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   PhylomeDB; Q46L08; -.
DR   Proteomes; UP000002535; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..640
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227460"
FT   DOMAIN          22..101
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          211..246
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   640 AA;  74128 MW;  CB360445DC4378CC CRC64;
     MELTPLIRDK SRLSDFLKDI PNDPGCYLMK DGEDRLLYVG KSKKLRNRVR SYFRSGNELS
     PRISLMVRQV ADIELIVTDN ESEALTLESN LIKSHQPYFN VLLKDDKKYP YVCITWGDKY
     PRIFLTRKRR QRQLKDKYYG PYVDVYLLRQ TLFSIKKLFP LRQRRIPLYK DRTCLNYSIG
     RCPGVCQEEI SSEDYKNTLK RVEMIFQGRT DELRILLEKQ MISFSESLKF EEAGSVRDQL
     KGIDRLYESQ KMIIPDSSVC RDIIAMASEE NISSVQIFQM RSGKLIGRLG YFSDNSNFNS
     SQILQQVIEN HYSNVDPVEI PSEILVQHQL VNNILISDWL SEIKKQKVNI NVPKRSRKAE
     IIKLVEKNAN LELQRIKQSQ DKNLVELDDL TNILDLENIP KRIECYDISH IQGSDAVASQ
     VVFIDGIAAR QHYRRYKIKS PNIKIGHSDD FESMAEVITR RFRRWARFKE EGGDIDALLS
     NESSVLDNLN LNDWPDLVVI DGGKGQLSSV VAALEGLKLD QNLNVISLAK KKEEVFIPKV
     KQSLVTESNQ PGMLLLRRLR DEAHRFAITF HRQKRSQRMK RSQLNEIPGL GPQRIKLLLE
     HFRSIEAIQM ATFSELSSTP GLGRSTAVVI RNYFHPDKNI