ID   UVRC_PSEAE              Reviewed;         608 AA.
AC   Q9I0Q1;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=PA2585;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE004091; AAG05973.1; -; Genomic_DNA.
DR   PIR; C83322; C83322.
DR   RefSeq; NP_251275.1; NC_002516.2.
DR   RefSeq; WP_003113354.1; NZ_QZGE01000008.1.
DR   AlphaFoldDB; Q9I0Q1; -.
DR   SMR; Q9I0Q1; -.
DR   STRING; 287.DR97_5460; -.
DR   PaxDb; Q9I0Q1; -.
DR   PRIDE; Q9I0Q1; -.
DR   EnsemblBacteria; AAG05973; AAG05973; PA2585.
DR   GeneID; 880581; -.
DR   KEGG; pae:PA2585; -.
DR   PATRIC; fig|208964.12.peg.2705; -.
DR   PseudoCAP; PA2585; -.
DR   HOGENOM; CLU_014841_3_0_6; -.
DR   InParanoid; Q9I0Q1; -.
DR   OMA; HIECFDN; -.
DR   PhylomeDB; Q9I0Q1; -.
DR   BioCyc; PAER208964:G1FZ6-2624-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..608
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138326"
FT   DOMAIN          16..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          204..239
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   608 AA;  67352 MW;  63D69A39E4CE4145 CRC64;
     MSAVFDASAF LATCSNRPGV YRMFDAEAKL LYVGKAKSLK KRLASYFRKS GLAPKTAALV
     ARIAQVETTI TANETEALLL EQTLIKEWRP PYNILLRDDK SYPFVFLSSE DEYPRLSLHR
     GAKKRKGRYF GPYPSAGAIR ESLNLLQKAF LVRQCEDSYF RNRTRPCLQY QIKRCKGPCV
     GLVSPEEYAE DVRHSVMFLE GRSNALADEL NVGMEQAAMR LDFEKAAELR DQVAILRRVQ
     DQQSMEGGNG DVDIVAAIVT PGGACVHLIS VRGGRVLGSK NFFPQVAIEE EVGEVLLAFL
     GQYYLSHQER DLPAELIVNV THEDFPVLVS AIAEARGREL EISYRVRGTR ARWQQLAVTN
     AEQALGARLA NRQHVAARFE ALAEALDLAE PPQRLECFDI SHSSGEATVA SCVVFGPEGP
     LKSDYRRYNI EGVTAGDDYA AMHQALTRRF SRLKDGEGKM PDILLVDGGK GQLAMAQEVL
     QELAVAGLIL LGVAKGVTRK PGLETLYLND ASHEFTLPAD SPALHLIQQI RDEAHRFAIT
     GHRARRGKAR RTSTLEDVPG VGPKRRRDLL KHFGGLQELS RASIDELAKA PGISKKLAEQ
     IYAVLHSE