UVRC_PSEPH
ID UVRC_PSEPH Reviewed; 607 AA.
AC P32966;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
OS Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1124983;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BL915;
RX PubMed=8075420; DOI=10.1094/mpmi-7-0455;
RA Gaffney T.D., Lam S.T., Ligon J., Gates K., Frazelle A., Maio J., Hill S.,
RA Goodwin S., Torkewitz N., Allshouse A.M., Kempf H.J., Becker J.O.;
RT "Global regulation of expression of antifungal factors by a Pseudomonas
RT fluorescens biological control strain.";
RL Mol. Plant Microbe Interact. 7:455-463(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-232.
RC STRAIN=DSM 19095 / LMG 27888 / CFBP 6595 / CHA0;
RX PubMed=1311842; DOI=10.1073/pnas.89.5.1562;
RA Laville J., Voisard C.P., Keel C., Maurhofer M., Difago G., Haas D.;
RT "Global control in Pseudomonas fluorescens mediating antibiotic synthesis
RT and suppression of black root rot of tobacco.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:1562-1566(1992).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; L29642; AAA98758.1; -; Genomic_DNA.
DR EMBL; M80913; AAA25822.1; -; Genomic_DNA.
DR AlphaFoldDB; P32966; -.
DR SMR; P32966; -.
DR STRING; 1124983.PFLCHA0_c36040; -.
DR eggNOG; COG0322; Bacteria.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.340; -; 1.
DR Gene3D; 3.40.1440.10; -; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_HhH_N; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; SSF46600; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF82771; SSF82771; 1.
DR TIGRFAMs; TIGR00194; uvrC; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW SOS response.
FT CHAIN 1..607
FT /note="UvrABC system protein C"
FT /id="PRO_0000138327"
FT DOMAIN 16..94
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 203..238
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT CONFLICT 3..4
FT /note="DP -> EQ (in Ref. 2; AAA25822)"
FT /evidence="ECO:0000305"
FT CONFLICT 28
FT /note="T -> A (in Ref. 2; AAA25822)"
FT /evidence="ECO:0000305"
FT CONFLICT 41
FT /note="S -> N (in Ref. 2; AAA25822)"
FT /evidence="ECO:0000305"
FT CONFLICT 44
FT /note="A -> S (in Ref. 2; AAA25822)"
FT /evidence="ECO:0000305"
FT CONFLICT 52
FT /note="L -> Q (in Ref. 2; AAA25822)"
FT /evidence="ECO:0000305"
FT CONFLICT 61
FT /note="G -> A (in Ref. 2; AAA25822)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="E -> D (in Ref. 2; AAA25822)"
FT /evidence="ECO:0000305"
FT CONFLICT 123
FT /note="K -> R (in Ref. 2; AAA25822)"
FT /evidence="ECO:0000305"
FT CONFLICT 184
FT /note="A -> P (in Ref. 2; AAA25822)"
FT /evidence="ECO:0000305"
FT CONFLICT 211..212
FT /note="AG -> TA (in Ref. 2; AAA25822)"
FT /evidence="ECO:0000305"
FT CONFLICT 215
FT /note="Q -> A (in Ref. 2; AAA25822)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 607 AA; 67303 MW; 179D412EC0B4398C CRC64;
MTDPFDPSAF LSTCSGRPGV YRMFDSDTRL LYVGKAKNLK SRLASYFRKT GLAPKTAALV
GRIAQIETTI TANETEALLL EQTLIKEWRP PYNILLRDDK SYPYVFLSDG EFPRFSIHRG
AKKQKGKYFG PYPSAGAIRE SLSLLQKTFM VRQCEDSYYK NRTRPCLQYQ IKRCKAPCVG
LVEAEVYAED VRHSVMFLEG RSNALTDELS AGMEQAASTL DFEKAAELRD QISLLRRVQD
QQSMEGGSGD VDVVAAFVNP GGACVHLISV RGGRVLGSKN FFPQVGIEEE VAEVMSAFLG
QYFLSSPERD LPSELIVNVV HEDFPALIAA IQELRGRELS ISHRVRGTRA RWQQLAVTNA
EQALSARLAN RQHVAARFEA LAEVLNLDEP PQRLECYDIS HSSGEATVAS CVVFGPEGPL
KSDYRRYNIE GVTAGDDYAA MHQALTRRFS KLKDGEGKLP DILLVDGGKG QLSMARDVLN
ELAVPDLILL GVAKGATRKT GFETLYLNDA AHEFTLKGDS PALHLIQQIR DEAHRFAITG
HRARRGKTRR TSTLEDVAGV GPKRRRDLLK HFGGLQELSR ASIEEIAKAP GISKKLAELI
YANLHSE
