ID   UVRC_PSEU2              Reviewed;         607 AA.
AC   Q52377; Q4ZSE2;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 2.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Psyr_2896;
OS   Pseudomonas syringae pv. syringae (strain B728a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX   NCBI_TaxID=205918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B728a;
RX   PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA   Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA   Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA   Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA   Kyrpides N.C., Ivanova N., Lindow S.E.;
RT   "Comparison of the complete genome sequences of Pseudomonas syringae pv.
RT   syringae B728a and pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-153.
RX   PubMed=8002569; DOI=10.1128/jb.176.24.7468-7475.1994;
RA   Rich J.J., Kinscherf T.G., Kitten T., Willis D.K.;
RT   "Genetic evidence that the gacA gene encodes the cognate response regulator
RT   for the lemA sensor in Pseudomonas syringae.";
RL   J. Bacteriol. 176:7468-7475(1994).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000075; AAY37930.1; -; Genomic_DNA.
DR   EMBL; U09767; AAA65232.1; -; Genomic_DNA.
DR   PIR; B55538; B55538.
DR   RefSeq; WP_011268071.1; NC_007005.1.
DR   RefSeq; YP_235968.1; NC_007005.1.
DR   AlphaFoldDB; Q52377; -.
DR   SMR; Q52377; -.
DR   STRING; 205918.Psyr_2896; -.
DR   EnsemblBacteria; AAY37930; AAY37930; Psyr_2896.
DR   KEGG; psb:Psyr_2896; -.
DR   PATRIC; fig|205918.7.peg.2952; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_6; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000426; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..607
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138330"
FT   DOMAIN          16..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          203..238
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   CONFLICT        5..26
FT                   /note="FDPGAFLATCSGRPGVYRMFDA -> LIQVHSRDCSVPASTVCRR (in
FT                   Ref. 2; AAA65232)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   607 AA;  67093 MW;  D02A5781DAD88613 CRC64;
     MTQTFDPGAF LATCSGRPGV YRMFDAEATL LYVGKAKNLK KRLASYFRKT GHAPKTGALV
     SRIAQIETTI TGNETEALLL EQTLIKEWRP PYNILLRDDK SYPYVFLSDN AFPRLSIHRG
     TKKAKGRYFG PYPSAGAIRE SLSLLQKTFQ VRQCEDSYFK NRTRPCLQYQ IKRCKGPCVG
     LVEPEVYAED VRHSVMFLEG RSNALSDELN ASMEKAAMAL DFERAAELRD QVALLRRVQD
     QQSMDGGTGD VDVVAAFVNP GGACVHLISV RGGRVLGSKN FFPQVGIEEE VGEVMSAFLA
     QYFLGGIDRE LPGEVIVNVI NDDFPAFVDA VEELRGVEMV ISHRVRGTRA RWQQMAVTNA
     EQALTARLAN RQHVASRFEA LAKVLGLEDP PMRLECYDIS HSSGEATVAS CVVFGPEGPI
     KSDYRRFNIE GVTAGDDYAA MHQALTRRYS RIKAGEGKLP DVLLVDGGKG QMSMARDVLN
     ELQVPELILL GVAKGTTRKA GFETLYLNDS AHEFTLPGDS PALHLIQQIR DEAHRFAITG
     HRARRGKTRR TSTLEGVAGV GPTRRRDLLK HFGGLQELSR ASIDEIAKAP GISKKLAESI
     YANLHSE