ID   UVRC_RHIEC              Reviewed;         679 AA.
AC   Q2KA54;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=RHE_CH01479;
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFN 42 / ATCC 51251;
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in
RT   seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000133; ABC90282.1; -; Genomic_DNA.
DR   RefSeq; WP_011424812.1; NC_007761.1.
DR   AlphaFoldDB; Q2KA54; -.
DR   SMR; Q2KA54; -.
DR   STRING; 347834.RHE_CH01479; -.
DR   EnsemblBacteria; ABC90282; ABC90282; RHE_CH01479.
DR   KEGG; ret:RHE_CH01479; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_5; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001936; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..679
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264930"
FT   DOMAIN          65..143
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          253..288
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   679 AA;  74885 MW;  D675343337480BFF CRC64;
     MNGRKLPDGG VLYDDTDESE DEIEVEGDVS AAPLAVAVDW NAGSLNETGL VGAELIGEFV
     KRLPNSPGVY RMLNAEGDVL YVGKARSLKK RVGNYAVGRV HSNRIAQMVR QTANMEFVTT
     RTETEALLLE ANLIKRLRPR FNVLLRDDKS FPYILITGDH RAPAIFKHRG ARARKGDYFG
     PFASAGAVGR TINSLQRAFL IRTCTDSVFE TRTRPCLLYQ IKRCSGPCTH EVSDEGYAEL
     VQEAKDFLSG KSQKVKSHMA EAMNQAAEDL DFERAAIYRD RLAALSHVQS HQGINPAGVD
     EADVFAIHHE GGVSCIQVFF FRTGQNWGNR AYFPKADPQL SSAEVLNAFL AQFYDDKPVP
     KQIMLSETAE ELELLAAALS EKAGHKVSIL VPRRGEKRDL VDHVVGNARE AHGRKLAETA
     SQSRLLEGFK ETFGLAYAPQ RIEIYDNSHI MGTNAVGGMV VAGPEGFVKN QYRKFNIKST
     DITPGDDFGM MKEVMTRRFS RLIKEEGIPD RTAQAAAADA ADMPFPAWPD VILIDGGQGQ
     MTAVRAILAE LGITDSVTAI GIAKGVDRDA GRERFFAPGR ESFTLPPRDP VLYFIQRMRD
     EAHRFAIGSH RVRRKKEMVK NPLDEIGGIG PSRKRALLQH FGTAKAVSRA ALSDLMAVEG
     ISEAVAKQVY NHFHEDAAK