ID   UVRC_RHOE4              Reviewed;         730 AA.
AC   C0ZZE8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=RER_30250;
OS   Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus;
OC   Rhodococcus erythropolis group.
OX   NCBI_TaxID=234621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887;
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus erythropolis
RT   PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AP008957; BAH33733.1; -; Genomic_DNA.
DR   RefSeq; WP_020907712.1; NC_012490.1.
DR   AlphaFoldDB; C0ZZE8; -.
DR   SMR; C0ZZE8; -.
DR   STRING; 234621.RER_30250; -.
DR   PRIDE; C0ZZE8; -.
DR   EnsemblBacteria; BAH33733; BAH33733; RER_30250.
DR   KEGG; rer:RER_30250; -.
DR   PATRIC; fig|234621.6.peg.3526; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_11; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000002204; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..730
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000204125"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          678..730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        715..730
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   730 AA;  79348 MW;  5538A7D47D14F890 CRC64;
     MPDPSTYRPA TGTIPAAPGV YKFRDPHGRV IYVGKAKSLR SRLNSYFADV TTLHPRTRQM
     VTTAGSVEWT VVSTEVEALQ LEYNWIKEFD PRFNVRYRDD KTYPVLAVTL NEEFPRLFVY
     RGPRRKGVRY FGPYSHAWAI RETLDLLLRV FPARTCSSGV FKRHNQIGRP CLLGYIDKCS
     APCVGRVSAE EHRQIVEDFC DFLAGRTDKL VKDLEKRMQQ ASEDLDFETA ARLRDDIGAL
     RKALEKQAVV LGDGTDADLV AFATDDLEAA VQVFHVRGGR VRGQRGWVVE KAGDAIDWAA
     LDAESDLPIL VEQFLTQFYG EQAALDPGAG SEAGISAVPK EVLVPVLPAN ATEIQAWLSK
     LRGSQVQLRV PQRGDKKDLA ETVQRNAKEA LAQHKLKRAG DFTSRSAALQ GIQEALDLDS
     APLRIECIDI SHVQGTDVVA SLVVFEDGLP RKSDYRHYAI KEAAGDGHSD DVASIAEITR
     RRFIRHNRDL GILAASASTM DADGGDLAPE AAIDPATGRP RRFAYPPNLF VVDGGAPQVT
     AAAAVLDELG VTDVAVVGLA KRLEEVWVPG EEDPVILPRT SESLYLLQRI RDEAHRFAIT
     FHRSKRSRRM TASALDSVKG LGETRRTALV AHFGSVAKLK TATVEEIMQV PGIGETTATA
     VLAALGTDSA AADAGAEARA LPAAVGDDEL DKESESSVTS ADAPSAESGS GDEGSESREL
     SMPTTGPSAQ