ID   UVRC_RHOJR              Reviewed;         727 AA.
AC   Q0S0J9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN   OrderedLocusNames=RHA1_ro07173;
OS   Rhodococcus jostii (strain RHA1).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=101510;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RHA1;
RX   PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA   McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C.,
RA   Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H.,
RA   Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H.,
RA   Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R.,
RA   Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W.,
RA   Eltis L.D.;
RT   "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT   catabolic powerhouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000431; ABG98937.1; -; Genomic_DNA.
DR   RefSeq; WP_011598874.1; NC_008268.1.
DR   AlphaFoldDB; Q0S0J9; -.
DR   SMR; Q0S0J9; -.
DR   STRING; 101510.RHA1_ro07173; -.
DR   EnsemblBacteria; ABG98937; ABG98937; RHA1_ro07173.
DR   KEGG; rha:RHA1_ro07173; -.
DR   PATRIC; fig|101510.16.peg.7227; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_11; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000008710; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..727
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264934"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          503..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          679..727
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   727 AA;  79474 MW;  F94A9CE9EF65CD05 CRC64;
     MPDPSTYRPA TGTIPVDPGV YKFRDPHGRV IYVGKAKSLR SRLNSYFADV STLHPRTRQM
     VTTAGSVEWT VVSTEVEALQ LEYNWIKEFD PRFNVRYRDD KTYPVLAVTL NEEYPRLFVY
     RGPRRKGVRY FGPYSHAWAI RETLDLLLRV FPARTCSAGV FKRHNQIGRP CLLGYIDKCS
     APCVGRVSAA EHRKIVEDFC DFLSGRTDRL VRQLEARMQE ASEELDFETA ARLRDDVGAL
     RRALEKQAVV LGDGTDADVA AFATDELEAA VQVFHVRGGR VRGQRGWVVE KAGDVIDWAS
     VDSEAGSDLP LLVEQFLTQF YGEQAALSGA TDQEAGTSGV PREVLVPVLP PDAEQVQEWL
     SGLRGSAVRL RVPQRGDKKA LAETVQRNAT EALQQHKLRR AGDFTSRSAA LQGIQEALDL
     DSAPLRIECV DISHVQGTDV VASLVVFEDG LPRKSDYRHY AIKEAAGDGR SDDVASIAEV
     TRRRFLRHNR DVGVLRAEAA GADADQVSGG DGGDLAPEAA IDPQTGRPRR FAYPPNLFVV
     DGGAPQVAAA SAVLDELGIT DVAVIGLAKR LEEVWVPGEE DPVILPRTSE SLYLLQRVRD
     EAHRFAITFH RSKRSRRMTA SALDSVRGLG ETRRKALVTH FGSVARLKQA SVEEITAVPG
     IGTATAKAVL TALGAEEPSA DVVGVGDDEP DRNGPGTAER NGADIPREPV EQHGPAAQSA
     SQRTGVE