ID   UVRC_RHOOB              Reviewed;         743 AA.
AC   C1B4L2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=ROP_69540;
OS   Rhodococcus opacus (strain B4).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=632772;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B4;
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus erythropolis
RT   PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AP011115; BAH55201.1; -; Genomic_DNA.
DR   RefSeq; WP_015890627.1; NC_012522.1.
DR   AlphaFoldDB; C1B4L2; -.
DR   SMR; C1B4L2; -.
DR   STRING; 632772.ROP_69540; -.
DR   EnsemblBacteria; BAH55201; BAH55201; ROP_69540.
DR   KEGG; rop:ROP_69540; -.
DR   PATRIC; fig|632772.20.peg.7245; -.
DR   HOGENOM; CLU_014841_3_2_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000002212; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..743
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000200597"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          497..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          694..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  80868 MW;  FED3C2C86EAEF1C7 CRC64;
     MPDPSTYRPA TGTIPVDPGV YKFRDPHGRV IYVGKAKSLR SRLNSYFADV STLHPRTRQM
     VTTAGSVEWT VVSTEVEALQ LEYNWIKEFD PRFNVRYRDD KTYPVLAVTL NEEYPRLFVY
     RGPRRKGVRY FGPYSHAWAI RETLDLLLRV FPARTCSAGV FKRHNQIGRP CLLGYIDKCS
     APCVGRVSAA EHRKIVEDFC DFLSGRTDKL VRQLEARMQQ ASEELDFETA ARLRDDVGAL
     RRALEKQAVV LGDGTDADVA AFATDELEAA VQVFHVRGGR VRGQRGWVVE KAGDVIDWAA
     VDSAAGSDLP LLVEQFLTQF YGEQAALSGA ADQEAGSSGV PREVLVPVLP PDAEQVQEWL
     SGLRGSAVRL RVPQRGDKKA LAETVQRNAM EALQQHKLRR AGDFTSRSAA LQGIQEALDL
     DSAPLRIECV DISHVQGTDV VASLVVFEDG LPRKSDYRHY AIKEAAGDGR SDDVASIAEV
     TRRRFLRHNR DVGVLRAEAA GADGDQASDT DGDQVSDTDG DQVSGGDGGD LAPEAAIDPQ
     TGRPRRFAYP PNLYVVDGGA PQVAAASAVL DELGITDVAV IGLAKRLEEV WVPGEEDPVI
     LPRTSESLYL LQRVRDEAHR FAITFHRSKR SRRMTASALD SVRGLGETRR KALVTHFGSV
     AKLKQASVEE ITAVPGIGTA TAKAVLTALG AEEPSADVAG VGDDEPDRTG PVTAERNGAD
     LPREPVGQHG PAAQSASQRT GVE