CAF1_YERPE
ID CAF1_YERPE Reviewed; 170 AA.
AC P26948;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 25-MAY-2022, entry version 150.
DE RecName: Full=F1 capsule antigen;
DE Flags: Precursor;
GN Name=caf1; OrderedLocusNames=YPMT1.84, Y1100, YP_pMT082;
OS Yersinia pestis.
OG Plasmid pMT1 (pMT-1), and Plasmid pFra.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC PLASMID=pFra;
RX PubMed=1702734; DOI=10.1016/0014-5793(90)80852-a;
RA Galyov E.E., Smirnov O.Y., Karlishev A.V., Volkovoy K.I., Denesyuk A.I.,
RA Nazimov I.V., Rubtsov K.S., Abramov V.M., Dalvadyanz S.M., Zav'Yalov V.P.;
RT "Nucleotide sequence of the Yersinia pestis gene encoding F1 antigen and
RT the primary structure of the protein. Putative T and B cell epitopes.";
RL FEBS Lett. 277:230-232(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis; PLASMID=pMT1 (pMT-1);
RX PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA Brubaker R.R., Garcia E.;
RT "Structural organization of virulence-associated plasmids of Yersinia
RT pestis.";
RL J. Bacteriol. 180:5192-5202(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis; PLASMID=pMT1 (pMT-1);
RX PubMed=9826348; DOI=10.1128/iai.66.12.5731-5742.1998;
RA Lindler L.E., Plano G.V., Burland V., Mayhew G.F., Blattner F.R.;
RT "Complete DNA sequence and detailed analysis of the Yersinia pestis KIM5
RT plasmid encoding murine toxin and capsular antigen.";
RL Infect. Immun. 66:5731-5742(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis; PLASMID=pMT1 (pMT-1);
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis; PLASMID=pMT1 (pMT-1);
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- INTERACTION:
CC P26948; P26926: caf1M; NbExp=6; IntAct=EBI-1036572, EBI-1036581;
CC -!- SUBCELLULAR LOCATION: Secreted, capsule.
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DR EMBL; X61996; CAA43966.1; -; Genomic_DNA.
DR EMBL; AF074611; AAC82758.1; -; Genomic_DNA.
DR EMBL; AF053947; AAC13218.1; -; Genomic_DNA.
DR EMBL; AL117211; CAB55266.1; -; Genomic_DNA.
DR EMBL; AE017045; AAS58714.1; -; Genomic_DNA.
DR PIR; S13008; S13008.
DR RefSeq; NP_395430.1; NC_003134.1.
DR RefSeq; NP_857692.1; NC_004835.1.
DR RefSeq; WP_002216410.1; NZ_WUCM01000058.1.
DR PDB; 1P5U; X-ray; 1.99 A; B=22-170, C=35-170.
DR PDB; 1P5V; X-ray; 1.70 A; B=35-170.
DR PDB; 1Z9S; X-ray; 2.20 A; B/C=22-170.
DR PDB; 3DOS; X-ray; 2.40 A; B/C/E/F=22-170.
DR PDB; 3DPB; X-ray; 2.20 A; B/C=22-170.
DR PDB; 3DSN; X-ray; 2.20 A; B/C/E/F=34-170.
DR PDB; 4AYF; X-ray; 2.07 A; B=22-170.
DR PDB; 4AZ8; X-ray; 2.65 A; B=22-170.
DR PDB; 4B0M; X-ray; 1.80 A; B=22-170.
DR PDBsum; 1P5U; -.
DR PDBsum; 1P5V; -.
DR PDBsum; 1Z9S; -.
DR PDBsum; 3DOS; -.
DR PDBsum; 3DPB; -.
DR PDBsum; 3DSN; -.
DR PDBsum; 4AYF; -.
DR PDBsum; 4AZ8; -.
DR PDBsum; 4B0M; -.
DR AlphaFoldDB; P26948; -.
DR SMR; P26948; -.
DR DIP; DIP-35243N; -.
DR IntAct; P26948; 2.
DR DNASU; 1149244; -.
DR EnsemblBacteria; AAC82758; AAC82758; AAC82758.
DR EnsemblBacteria; AAS58714; AAS58714; YP_pMT082.
DR GeneID; 57977636; -.
DR KEGG; ype:YPMT1.84; -.
DR KEGG; ypk:caf1.pl; -.
DR KEGG; ypm:YP_pMT082; -.
DR PATRIC; fig|214092.21.peg.212; -.
DR HOGENOM; CLU_1570061_0_0_6; -.
DR OMA; GNIPQPW; -.
DR EvolutionaryTrace; P26948; -.
DR PRO; PR:P26948; -.
DR Proteomes; UP000000815; Plasmid pMT1 (pMT-1).
DR Proteomes; UP000001019; Plasmid pMT1.
DR Proteomes; UP000002490; Plasmid pMT-1.
DR GO; GO:0042603; C:capsule; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0009289; C:pilus; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.1090; -; 1.
DR InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR InterPro; IPR008966; Adhesion_dom_sf.
DR InterPro; IPR015335; Caf1.
DR Pfam; PF09255; Antig_Caf1; 1.
DR SUPFAM; SSF49401; SSF49401; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Capsule; Plasmid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..170
FT /note="F1 capsule antigen"
FT /id="PRO_0000020839"
FT REGION 100..150
FT /note="Contains potential antigenic determinants that may
FT stimulate T-cells"
FT STRAND 24..35
FT /evidence="ECO:0007829|PDB:1P5U"
FT STRAND 38..46
FT /evidence="ECO:0007829|PDB:1P5V"
FT STRAND 50..52
FT /evidence="ECO:0007829|PDB:1P5U"
FT STRAND 54..56
FT /evidence="ECO:0007829|PDB:3DOS"
FT STRAND 63..70
FT /evidence="ECO:0007829|PDB:1P5V"
FT HELIX 78..80
FT /evidence="ECO:0007829|PDB:1P5V"
FT STRAND 81..84
FT /evidence="ECO:0007829|PDB:1P5V"
FT STRAND 93..101
FT /evidence="ECO:0007829|PDB:1P5V"
FT STRAND 104..112
FT /evidence="ECO:0007829|PDB:1P5V"
FT STRAND 128..130
FT /evidence="ECO:0007829|PDB:1P5V"
FT STRAND 137..148
FT /evidence="ECO:0007829|PDB:1P5V"
FT STRAND 156..168
FT /evidence="ECO:0007829|PDB:1P5V"
SQ SEQUENCE 170 AA; 17666 MW; 9AC87796A0BA67D9 CRC64;
MKKISSVIAI ALFGTIATAN AADLTASTTA TATLVEPARI TLTYKEGAPI TIMDNGNIDT
ELLVGTLTLG GYKTGTTSTS VNFTDAAGDP MYLTFTSQDG NNHQFTTKVI GKDSRDFDIS
PKVNGENLVG DDVVLATGSQ DFFVRSIGSK GGKLAAGKYT DAVTVTVSNQ
