ID   UVRC_RHORT              Reviewed;         639 AA.
AC   Q2RS75;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Rru_A2220;
OS   Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 /
OS   NCIMB 8255 / S1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Rhodospirillum.
OX   NCBI_TaxID=269796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1;
RX   PubMed=21886856; DOI=10.4056/sigs.1804360;
RA   Munk A.C., Copeland A., Lucas S., Lapidus A., Del Rio T.G., Barry K.,
RA   Detter J.C., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D.,
RA   Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Kyrpides N.C.,
RA   Mavromatis K., Richardson P., Rohde M., Goeker M., Klenk H.P., Zhang Y.,
RA   Roberts G.P., Reslewic S., Schwartz D.C.;
RT   "Complete genome sequence of Rhodospirillum rubrum type strain (S1).";
RL   Stand. Genomic Sci. 4:293-302(2011).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000230; ABC23020.1; -; Genomic_DNA.
DR   RefSeq; WP_011389875.1; NC_007643.1.
DR   RefSeq; YP_427307.1; NC_007643.1.
DR   AlphaFoldDB; Q2RS75; -.
DR   SMR; Q2RS75; -.
DR   STRING; 269796.Rru_A2220; -.
DR   PRIDE; Q2RS75; -.
DR   EnsemblBacteria; ABC23020; ABC23020; Rru_A2220.
DR   KEGG; rru:Rru_A2220; -.
DR   PATRIC; fig|269796.9.peg.2317; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_5; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   PhylomeDB; Q2RS75; -.
DR   Proteomes; UP000001929; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..639
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264940"
FT   DOMAIN          42..120
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          230..265
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   639 AA;  70458 MW;  488CA7586DB00E8B CRC64;
     MTDLPVDEPD RDDGADQPDA GADPATPRGV EAIRAALRTM PSSPGVYRMI DGKGDVLYVG
     KARNLKRRVI NYTQPHRLPV RIQRMIAATL TMEVLTTHTE AEALLLESNL IKKLKPRYNI
     LLRDDKSFPY IEITSDHAFP RIVKFRGTLR KGGEYFGPFA SAGAVTSTLT ALQKTFLLRT
     CADNVFASRS RPCLLFQIKR CAAPCVDRVA EADYKALVEE ARAFLSGSSK ALQHDLAKRM
     DEAAQALDYE QAAIFRDRIK ALTNVQSHQD INLPTLGEAD VIACHQAGGQ TCVQVFFFRG
     GRNNGNRSFF PAHAGDEGLP EVLEAFLGQF YAGFPPPREI LLLTDIPHHD LVEQALCLRA
     GHRVRLVVPR RGSRRKLIDH ALANAREALG RRLAESSAQR TLLEGTAVAF GLDGPLQRVE
     IYDNSHISGT HAVGGMVVAG PEGFMKAAYR KFNIRSPDIT PGDDYAMMRE VMIRRFARAR
     KEDPDRDRGQ WPDLVLIDGG LGQLNAVREA LAEIGVEDVP LVGVAKGPDR DAGRERFFVP
     GRPPFMLRHN DPVLYFIQRL RDEAHRFAIG SHRTRRSKAI GVSPLDSVPG IGASRKKALL
     HHFGSAKAVS QAGLTDLEAV EGISAALAKK LYDHFHSEG