ID   UVRC_RICAH              Reviewed;         651 AA.
AC   A8GP33;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=A1C_04430;
OS   Rickettsia akari (strain Hartford).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=293614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hartford;
RA   Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Dasch G., Eremeeva M.;
RT   "Complete genome sequence of Rickettsia akari.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000847; ABV75158.1; -; Genomic_DNA.
DR   RefSeq; WP_012149788.1; NC_009881.1.
DR   AlphaFoldDB; A8GP33; -.
DR   SMR; A8GP33; -.
DR   STRING; 293614.A1C_04430; -.
DR   EnsemblBacteria; ABV75158; ABV75158; A1C_04430.
DR   KEGG; rak:A1C_04430; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_5; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000006830; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 2.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..651
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077825"
FT   DOMAIN          20..97
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          207..242
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   651 AA;  74557 MW;  62FC4E8260DD17A0 CRC64;
     MTLEITRSEL IKSKLIDAPE RCGVYRMFDV NKQVIYVGKA KNLKKRLTHY IKSDLDNKTL
     RMIANTCFLE YSITNSEVEA LLLEAQLIKK FQPKFNILLK DDKSFPFIKL RLDHDFPQLL
     KYRGKTLNDG KCFGPFASAT EVNTTLTELQ KIFKLRSCTD NYFNSRTRPC MQYEIKRCYA
     PCVGKINKED YRDLVAQVKD FLQGRTKALQ ENLSKKMEEL SSQMRFEEAA EIRDRIKALS
     YVQLKSCVSD IVKDADIIVV VEKNGHYCVE VFLYRAWQAC GNIPYFPTST ENSTKEEVLE
     YFLLQFYQKQ QVPAEIIINH EINDKENMIE AIKKINNITK LNIIIPISGG KAKLVQNAAI
     KALFSLEQYL KKFVKNQEIM LEIKALFGLH EIPERIEIYD NSHIQGKFAV GVVVVVGKAG
     FDKKEYRVFS LSSCDASLSS HAYPFSPRNL IAGSSTLTNP MDPVVRSRED DTSSTHNYAV
     GDDYEMLRQV LIRRLTRLKN EPHKLPSLMI IDGGKGHLGI VKEVMDKFAM HIPFVCMSKG
     VDRNAGIEQF HMTGKEVFTL DTNLPIMKYL QILRDEAHNF AIKNHRLGRS RAIKISSLDN
     IEGVGETRKK ALLHYFGSYK AVCDATIDEL TKVNGINKSL AAMIFRTLHK R