ID   UVRC_RICBR              Reviewed;         635 AA.
AC   Q1RIW9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=RBE_0614;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RML369-C;
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae in
RT   gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000087; ABE04695.1; -; Genomic_DNA.
DR   RefSeq; WP_011477283.1; NC_007940.1.
DR   AlphaFoldDB; Q1RIW9; -.
DR   SMR; Q1RIW9; -.
DR   STRING; 336407.RBE_0614; -.
DR   PRIDE; Q1RIW9; -.
DR   EnsemblBacteria; ABE04695; ABE04695; RBE_0614.
DR   KEGG; rbe:RBE_0614; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_5; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000001951; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR022439; RPE4.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR03777; RPE4; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..635
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264941"
FT   DOMAIN          20..97
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          207..242
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   635 AA;  72695 MW;  36BC8CB9F670E7A8 CRC64;
     MTMELTGNEL IKSKLIDIPE RSGVYRMFDA NKQVIYVGKA KNLKKRLTNY IKTDLDTKTL
     RMVANTCSLE YSITNSEVEA LLLEAQLIKK FQPKFNILLK DDKSFPFIKL RLDHDFPQLL
     KYRGRALNDG KFFGPFASAT EVNTTLSELQ KIFKLRSCTD NYFNSRTRPC LQYEIKRCYA
     PCVGKINKKD YAELVGQVKD FLQGRSKELQ ENLSKKMEEL SEQMRFEEAA EIRDRIKALS
     YVQLKAGITD IVKDADIIAI VEKNGHYCVE VFLYRIGQAC GNIPYFPTST ENSTKEEVLK
     HFLLQFYQKQ QVPPGIIINH EIDDKDNIIE AIRNINDFAK LSITIPASGG KLKLVQNAQE
     NALFSLEQYL KKFAKNQELM FEVKELFNLP EIPERIEVYD NSHIQGKFAV GVMIVAGKSG
     FDKKEYRVFS LSSRDSITGS SKSTNNDSIS CFLDTVDKPR YDTKGDDYEM LRQVLTRRLT
     RLKQEPHRLP SLMIIDGGKG HLGIVKEVMN KLQMDIPFVC MSKGPDRNAG LEQFHMVGRE
     VFTLNKNLPL MKYLQILRDE AHNFAIKNHR LSRSRAIKVS SLDEIEGIGD TRKKALLHYF
     GSYKAVSDAT LDELSKVKGI SKSLAKMIFN ALHKN