ID   UVRC_RICCK              Reviewed;         638 AA.
AC   A8EYB9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=A1E_02035;
OS   Rickettsia canadensis (strain McKiel).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=293613;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=McKiel;
RA   Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Dasch G., Eremeeva M.;
RT   "Complete genome sequence of Rickettsia canadensis.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000409; ABV73352.1; -; Genomic_DNA.
DR   RefSeq; WP_012148551.1; NC_009879.1.
DR   AlphaFoldDB; A8EYB9; -.
DR   SMR; A8EYB9; -.
DR   STRING; 293613.A1E_02035; -.
DR   PRIDE; A8EYB9; -.
DR   EnsemblBacteria; ABV73352; ABV73352; A1E_02035.
DR   KEGG; rcm:A1E_02035; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_5; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000007056; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..638
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077826"
FT   DOMAIN          20..97
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          209..244
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   638 AA;  72717 MW;  9328398468F8C451 CRC64;
     MTSDATGSEL IKSKLVDAPE CAGVYQMFDV NKQVIYVGKA KNLKKRLTNY IKLDLDNKTL
     RMIANTCFLE YSVTSSEVEA LLLEAQLIKK FQPKFNILLK DDKSFPFIKL RLDHDFPQLL
     KYRGRTRTLS DGKFFGPFAS ATAVNTTLTE LQKIFKLRSC TDNYFNSRNR PCLQYEIKRC
     YAPCISKINK KDYAELVIQV TAFLQGHTKE LQENLSKKME ELSSHMYFEE AAEIRDRIKA
     LSYVQLKAGI SDIVKDADIM AIVEKNGHYC VEVCLYRAGQ ACGTIPYFPT AMGNNTKEAI
     LKYFLLQFYQ KQQLPSEIII NNEVEDKEDV IEAIKKINNI TKLNIILPIS GGKAKLVQNA
     TTNALFSLEQ YLKKFAKNQE IMLEIKELFD LSEIPERIEI YDNSHIQGKF AVGVMVVAGK
     SGFDKKEYRV FSLSSHDSIT GFSTLTNNLD PVVKQQYDTN GTYNTTVGDD YDMFRQVLTR
     RLTRLKQEPY KLPSLMIIDG GRGHVGIVKE VMDKFKMNIP FVCMSKGPDR NAGLEQFHMV
     GKEVFTLDKN LPVMKYLQIL RDAAHSFAIK NHRLGRSRTI KLSSLDNIKG IGKTRKKSLL
     HYFGSYKAVC DATIDELVKV HGISKSLAEM IFRTLHQS