ID   UVRC_RICCN              Reviewed;         639 AA.
AC   Q92HA7;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=RC0864;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE006914; AAL03402.1; -; Genomic_DNA.
DR   PIR; H97807; H97807.
DR   RefSeq; WP_010977470.1; NC_003103.1.
DR   AlphaFoldDB; Q92HA7; -.
DR   SMR; Q92HA7; -.
DR   EnsemblBacteria; AAL03402; AAL03402; RC0864.
DR   KEGG; rco:RC0864; -.
DR   PATRIC; fig|272944.4.peg.981; -.
DR   HOGENOM; CLU_014841_3_2_5; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..639
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138331"
FT   DOMAIN          20..97
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          207..242
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   639 AA;  73354 MW;  63184CAA70972495 CRC64;
     MTLEITGSEL IKSKLIDAPE RSGVYRMFDV NKQVLYVGKA KNLKKRLTNY IKSNLDNKTL
     RMIANTCFLE YSITNSEVEA LLLEAQLIKK FQPKFNILLK DCKSFPFIKL RLDHDFPQLL
     KYRGKTLSDG KFFGPFASSV EVNTTLTELQ KIFKLRSCTD NYFNSRTRPC LQYEIKRCYA
     PCVGKINKED YRDLVTQVKD FLQGRTKELQ ENLSRKMEEL SSQMRFEEAA EIRDRIKALS
     YVQLKAGVSD VVKDADIIAI VEKNGHYCVE VFLYRAGQAC GNIPYFPTAT ENSTKEEVLE
     YFLLQFYQKQ HVPAAIIINH EINDKENVIE AIKKINNILQ INITVPNKGG KAKLVQNAET
     HALFSLEQYL KKFAKNQEIM FEIKELFGLS EIPERIEIYD NSHIQGKFAV GVMVVAGKVG
     FDKKEYRVFN VHTPSLVCHS RESGDPKRLM DSCFRGNGIK NCGGDIKGDD YEMLRQVLTR
     RLTRLRQEPH KLPSLMIIDG GKGHLGVVKE VMDKFEMNIP FVCMSKGVDR NAGFEQFHVI
     GKEVFTLDKN LPVMKYLQIL RDEAHNFAIK NHRLGRSRAI KISRLDDIEG VGETRKKALL
     HYFGSYKAVC DATIYELAKV NGINKLLAEM IFNVLHRKN