ID   CAF20_ASHGO             Reviewed;         147 AA.
AC   Q756C2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Cap-associated protein CAF20;
GN   Name=CAF20; OrderedLocusNames=AER345W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Acts as an inhibitor of cap-dependent translation. Competes
CC       with eIF4G1 and EAP1 for binding to eIF4E and interferes with the
CC       formation of the eIF4F complex, inhibiting translation and stabilizing
CC       mRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CAF20 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS53025.1; -; Genomic_DNA.
DR   RefSeq; NP_985201.1; NM_210555.1.
DR   AlphaFoldDB; Q756C2; -.
DR   SMR; Q756C2; -.
DR   STRING; 33169.AAS53025; -.
DR   EnsemblFungi; AAS53025; AAS53025; AGOS_AER345W.
DR   GeneID; 4621415; -.
DR   KEGG; ago:AGOS_AER345W; -.
DR   eggNOG; ENOG502S2E7; Eukaryota.
DR   HOGENOM; CLU_128343_0_0_1; -.
DR   InParanoid; Q756C2; -.
DR   OMA; GHFNRRR; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005845; C:mRNA cap binding complex; IEA:InterPro.
DR   GO; GO:0008190; F:eukaryotic initiation factor 4E binding; IEA:EnsemblFungi.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0010606; P:positive regulation of cytoplasmic mRNA processing body assembly; IEA:EnsemblFungi.
DR   GO; GO:0045727; P:positive regulation of translation; IEA:EnsemblFungi.
DR   InterPro; IPR031456; Caf20.
DR   Pfam; PF17052; CAF20; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis;
KW   Protein synthesis inhibitor; Reference proteome; Translation regulation.
FT   CHAIN           1..147
FT                   /note="Cap-associated protein CAF20"
FT                   /id="PRO_0000330083"
FT   REGION          46..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..64
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   147 AA;  16433 MW;  7285B2D231804A69 CRC64;
     MAKYTEEELL QLKPTYDVAV NFDVDAFKAM IAEVAEHHEI ADLFHQKARR RSSHHHGVKP
     KIKAHKPRIT TDDDGWCTST RKTSVVAVGD DGEPSPAFVA QETLRVKPNN KNIASSRPAD
     TRDIVADKPT MSFNAFAALE SDDEDQF