ID   UVRC_RICPU              Reviewed;         639 AA.
AC   C4K1I8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=RPR_03395;
OS   Rickettsia peacockii (strain Rustic).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=562019;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rustic;
RX   PubMed=20027221; DOI=10.1371/journal.pone.0008361;
RA   Felsheim R.F., Kurtti T.J., Munderloh U.G.;
RT   "Genome sequence of the endosymbiont Rickettsia peacockii and comparison
RT   with virulent Rickettsia rickettsii: identification of virulence factors.";
RL   PLoS ONE 4:E8361-E8361(2009).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP001227; ACR47439.1; -; Genomic_DNA.
DR   AlphaFoldDB; C4K1I8; -.
DR   SMR; C4K1I8; -.
DR   EnsemblBacteria; ACR47439; ACR47439; RPR_03395.
DR   KEGG; rpk:RPR_03395; -.
DR   HOGENOM; CLU_014841_3_2_5; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000005015; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..639
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000204127"
FT   DOMAIN          20..97
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          207..242
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   639 AA;  73319 MW;  A1328AAC10D4C07E CRC64;
     MTLEITGSEL IKSKLIDAPE RSGVYRMFDV NKQVLYVGKA KNLKKRLTNY IKSNLDNKTL
     RMIANTCFLE YSITNSEVEA LLLEAQLIKK FQPKFNILLK DCKSFPFIKL RLDHDFPQLL
     KYRGKTLSDG KFFGPFASSA EVNTTLTELQ KIFKLRSCTD NYFNSRTRPC LQYEIKRCYA
     PCVGKINKED YRDLVTQVKD FLQGRTKELQ ENLSRKMEEL SSQMRFEEAA EIRDRIKALS
     YVQLKAGVSD VVKDADIIAI VEKNGHYCVE VFLYRAGQAC GNIPYFPTST ENSTKEEVLE
     YFLLQFYQKQ HVPAAIIINH EINDKENVIE AIKKINNILQ LNITVPNKGG KAKLVQNAET
     NALFSLEQYL KKFAKNQEIM FEIKELFGLS EIPERIEIYD NSHIQGKFAV GVMVVAGKVG
     FDKKEYRVFN VHAPSLVCHS RESGDPKRLM DSCFRGNGIK NCGGDIKGDD YEMLRQVLTR
     RLTRLRQEPH KLPSLMIIDG GKGHLGVVKE VMDKFEMNIP FVCMSKGVDR NTGFEQFHVI
     GKEVFTLDKN LPVMKYLQIL RDEAHNFAIK NHRLGRSRAI KISRLDDIEG VGETRKKALL
     HYFGSYKAVC DATIYELAKV NGINKLLAEM IFNVLHRKN