ID   UVRC_RICRO              Reviewed;         639 AA.
AC   B0BYA6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=RrIowa_1026;
OS   Rickettsia rickettsii (strain Iowa).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=452659;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Iowa;
RX   PubMed=18025092; DOI=10.1128/iai.00952-07;
RA   Ellison D.W., Clark T.R., Sturdevant D.E., Virtaneva K., Porcella S.F.,
RA   Hackstadt T.;
RT   "Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and
RT   avirulent Rickettsia rickettsii Iowa.";
RL   Infect. Immun. 76:542-550(2008).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000766; ABY72832.1; -; Genomic_DNA.
DR   RefSeq; WP_012151028.1; NC_010263.3.
DR   AlphaFoldDB; B0BYA6; -.
DR   SMR; B0BYA6; -.
DR   STRING; 452659.RrIowa_1026; -.
DR   EnsemblBacteria; ABY72832; ABY72832; RrIowa_1026.
DR   GeneID; 45539407; -.
DR   KEGG; rrj:RrIowa_1026; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_5; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000796; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..639
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077827"
FT   DOMAIN          20..97
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          207..242
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   639 AA;  73408 MW;  711C4E8B237ECE2C CRC64;
     MTLEITGSEL IKSKLIDAPE RSGVYRMFDV NKQVLYVGKA KNLKKRLTNY IKSNLDNKTL
     RMIANTCFLE YSITNSEVEA LLLEAQLIKK FQPKFNILLK DCKSFPFIKL RLEHDFPQLL
     KYRGKTLSDG KFFGPFASSV DVNTTLTELQ KIFKLRSCTD NYFNSRTRPC LQYEIKRCYA
     PCVGKINKED YRDLVTQVKD FLQGRTKELQ ENLSRKMEEL SSQMRFEEAA EIRDRIKALS
     YVQLKAGVSD VVKDADIIAI VEKNGHYCVE VFLYRAGQAC GNIPYFPTST ENSTKEEVLE
     YFLLQFYQKQ HVPAAIIINH EINDKENVIE AIKKINNILQ LNITVPNKGG KAKLVQNAEI
     NALFSLEQYL KKFAKNQEII FEIKELFGLS AIPERIEIYD NSHIQGKFAV GVMVVAGKVG
     FDKKEYRVFN VYAPSLVCHS RESGDPKRLM DSCFRGNGIK NCWGDIKGDD YEMLRQVLTR
     RLTRLRQEPH KLPSLMIIDG GKGHLGVVKE VMDKFEMNIP FVCMSKGVDR NAGFEQFHVI
     GKEVFTLDKN LPVMKYLQIL RDEAHNFAIK NHRLGRSRAI KISRLDDIEG VGETRKKALL
     HYFGSYKAVC DATIYELAKV NGINKLLAEM IFNVLHRKN