ID   UVRC_SACEN              Reviewed;         717 AA.
AC   A4FBL9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=SACE_2138;
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC   2338;
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AM420293; CAM01444.1; -; Genomic_DNA.
DR   RefSeq; WP_011873579.1; NZ_PDBV01000001.1.
DR   AlphaFoldDB; A4FBL9; -.
DR   SMR; A4FBL9; -.
DR   STRING; 405948.SACE_2138; -.
DR   EnsemblBacteria; CAM01444; CAM01444; SACE_2138.
DR   KEGG; sen:SACE_2138; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_1_1_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..717
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077829"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          517..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          696..717
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   717 AA;  78168 MW;  AA806D8DA33C08D2 CRC64;
     MADPSTYRPA PGTIPDAPGV YRFHDAEGRV IYVGKAKSLR SRLSSYFADL SGLHPRTRQM
     VTTATGVRWT VVGTEVEALQ LEYSWIKEYD PRFNVRYRDD KSYPVLAVTL HEDFPRLYVT
     RGPRRKGVRY FGPYAHAWAI RETLDMLLRV FPARTCSAGV FKRHSQIGRP CLLGYIGKCS
     APCVGRVDAD EHRRIVEDFC DFFAGRTDTL IRKLDREMRQ ASEELEFERA ARLRDDLEAL
     RRAMEKQAVV LGDGTDADVI AFADDELAAA VQVFHIRGGR VRGQRGWVID KVEETGTAAL
     AERFLTQFYG EQAALAEQAD AGGTPVPREV LVPELPPECE AITEWLSGLR GGRVAVRVPQ
     RGDKRALMET VERNAKEAFT QYKLRRAGDL TARSAALQEL QDALGLDTAP LRIECIDVSH
     VQGTDVVASL VVFEDGVPRK SEYRRFAVRE GAEGGDVGSI AEVVRRRFAR YLKETAPPQE
     GGNGSAGATA AVENGSTDTV AANGSVGTAA GNGSAHTAAG NGLADTAAGE PEADVAVTPQ
     EAERTGIDPE TGRPRKFAYP PNLLVIDGGA PQANAAADAL TELGITDVAV IGIAKRLEEV
     WLPDEAEPVI LPRTSEALYL LQRVRDAAHD FAIRYHRQKR SKRMKSSTLD SIPGLGEARR
     TALLKHFGSL RRLRQATVEE ISAVPGFGQR TAETVHAALA AGGGTGESRD NAEGESQ