ID   UVRC_SALAI              Reviewed;         660 AA.
AC   A8LW31;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Sare_3337;
OS   Salinispora arenicola (strain CNS-205).
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Salinispora.
OX   NCBI_TaxID=391037;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNS-205;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K., Jenkins C.,
RA   Udwary D., Xiang L., Gontang E., Richardson P.;
RT   "Complete sequence of Salinispora arenicola CNS-205.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000850; ABV99140.1; -; Genomic_DNA.
DR   RefSeq; WP_012183433.1; NC_009953.1.
DR   AlphaFoldDB; A8LW31; -.
DR   SMR; A8LW31; -.
DR   STRING; 391037.Sare_3337; -.
DR   EnsemblBacteria; ABV99140; ABV99140; Sare_3337.
DR   GeneID; 5708292; -.
DR   KEGG; saq:Sare_3337; -.
DR   PATRIC; fig|391037.6.peg.3366; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_2_0_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..660
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077830"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          469..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  73330 MW;  B0D0BF656913C2BD CRC64;
     MADPSSYRPA PGTIPESPGV YRFRDGTGRV IYVGKARNLR SRLNSYFADP VNLHQRTRQM
     VFTAESVDWI SVATEVEALQ QEFTEIKQYD PRFNVRYRDD KSYPYLAVTV DEEFPRLQVM
     RGAKRRGVRY FGPYSHAWAI RETLDLLLRV FPARTCSSGV FKRAGQVGRP CLLGYIGKCS
     APCVGSVSAE EHRDIVNGFC DFMAGRTDAM VRRLEREMAE ASAELEFERA ARLRDDLAAL
     RRAMEKQTVV FGDGTDADVV AFADDPLEAA VQVFHVRDGR IRGQRGWVVE KTEDLTAGDL
     VHHFCTQVYG GEHGEAHVPR ELLVPELPAD VEALADWLSE HRGSRVTLRV PQRGDKRALL
     ETVARNATDA LARHKLKRAG DLTTRSKALD EIADTLGMRT APLRIECFDI SQIQGTDVVA
     SMVVFEDGLP RKSEYRRFII RGATDDLSAM SEVLRRRFAR YLDARAETGE AGVESAGDPD
     APAGPDAPDE PRVGTLVDPT TGRPRKFAYP PQLVVVDGGA PQVAAAAQAL AELGVDDVAL
     CGLAKRLEEV WLPDDDFPAI LPRTSEGLYL LQRVRDEAHR FAITFHRQRR SRRMTESALD
     RVSGLGEVRR KALLRHFGSL KRLAAASVEE ITEVPGIGKR TAEAILAALA DPTGQSEPRR