ID   UVRC_SALRD              Reviewed;         633 AA.
AC   Q2S280;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=SRU_1580;
OS   Salinibacter ruber (strain DSM 13855 / M31).
OC   Bacteria; Bacteroidetes; Bacteroidetes Order II. Incertae sedis;
OC   Rhodothermaceae; Salinibacter.
OX   NCBI_TaxID=309807;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13855 / CECT 5946 / M31;
RX   PubMed=16330755; DOI=10.1073/pnas.0509073102;
RA   Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H.,
RA   Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K.,
RA   Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L.,
RA   Legault B., Rodriguez-Valera F.;
RT   "The genome of Salinibacter ruber: convergence and gene exchange among
RT   hyperhalophilic bacteria and archaea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000159; ABC46304.1; -; Genomic_DNA.
DR   RefSeq; WP_011404327.1; NC_007677.1.
DR   RefSeq; YP_445701.1; NC_007677.1.
DR   AlphaFoldDB; Q2S280; -.
DR   SMR; Q2S280; -.
DR   STRING; 309807.SRU_1580; -.
DR   EnsemblBacteria; ABC46304; ABC46304; SRU_1580.
DR   KEGG; sru:SRU_1580; -.
DR   PATRIC; fig|309807.25.peg.1634; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_10; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000008674; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..633
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264944"
FT   DOMAIN          21..100
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          214..249
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   633 AA;  72316 MW;  416076E21109CF27 CRC64;
     MSEVLDDKPE VLVQKLDALP TDPGVYKFLD DEESVLYVGK AKNLRNRVRT YFQQSRQRDG
     RIEVMVQKAV DVDIIVTDTE AEALILENNQ IKELQPRYNV NLRDDKTYPY ICIKNERFPR
     VFKTRTVKQD GSEYFGPYAD VSKMNSMMDA IRSVFQLRTC SLDLTEEKIE AGKYDVCLQH
     HIDNCKAPCV GKQSEADYME TIEQVKKLLN GQTQELMDLL KDEMQRQSDA HNFEEAARLR
     DQVKALKDYS QQQKVVSQDF ADRDVFALHV ERDEDIGCGV LFQVREGKMI GKRHKFLRSV
     EERSDAELIL SLVENYYAEA NFYPEEVLLS HDPNDHPAQD THALEELLRQ EQGHQVPIKV
     PQRGEKASLV RMATSNAKLQ VGEWKTQQMK RERNRIPESI KALGEALNME APPRRVDGID
     VSHHGGKETV ASCVVFTDAT PRKSDYRTYK IRSTEEGTPD DYKAMREVVR RRYRRMVEED
     GPWPDLVVID GGKGQLSSAV EMLKEVGAFD RFPVIGLAKR LEEVYRPGDS DPVFLAKDSP
     ALQLLQKVRD EAHRFAVTYQ RKRRKKKTLQ SELLDIHGIG PKTAKKLLGE FGSAAKVKEA
     DEEALAEVVG PAKAETITDY YDETEAPAPA ETE