ID   UVRC_SALTO              Reviewed;         665 AA.
AC   A4X9H1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Strop_3109;
OS   Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440).
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Salinispora.
OX   NCBI_TaxID=369723;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-916 / DSM 44818 / CNB-440;
RX   PubMed=17563368; DOI=10.1073/pnas.0700962104;
RA   Udwary D.W., Zeigler L., Asolkar R.N., Singan V., Lapidus A., Fenical W.,
RA   Jensen P.R., Moore B.S.;
RT   "Genome sequencing reveals complex secondary metabolome in the marine
RT   actinomycete Salinispora tropica.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:10376-10381(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000667; ABP55545.1; -; Genomic_DNA.
DR   RefSeq; WP_012014322.1; NC_009380.1.
DR   AlphaFoldDB; A4X9H1; -.
DR   SMR; A4X9H1; -.
DR   STRING; 369723.Strop_3109; -.
DR   EnsemblBacteria; ABP55545; ABP55545; Strop_3109.
DR   KEGG; stp:Strop_3109; -.
DR   PATRIC; fig|369723.5.peg.3200; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_2_0_11; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000235; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..665
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077832"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          470..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   665 AA;  73708 MW;  0002825DC6F4A3C8 CRC64;
     MADPSSYRPA PGTIPESPGV YRFRDGTGRV IYVGKARNLR NRLNSYFADP VNLHQRTRQM
     VFTAESVDWI SVATEVEALQ QEFTEIKQYD PRFNVRYRDD KSYPYLAVTV SEEFPRLQVM
     RGAKRKGVRY FGPYSHAWAI RETLDLLLRV FPARTCSSGV FKRAGQVGRP CLLGYIDKCA
     APCVGSVSAE EHRAIVEGFC DFMAGRTDLM VRRLEREMAD ASAELEFERA ARLRDDLAAL
     RRAMEKQTVV FGDGTDADVV AFADDPLEAA VQVFHVRDGR IRGQRGWVVE KTEELTIGDL
     VHHFCTQVYG GEQGEADVPR ELLVPELPAD VEALADWLSD HRGSRVTLRV PQRGDKRALL
     ETVARNATDA LARHKLKRAG DLTTRSKALD EIAETLGLQT APLRIECYDI SQIQGTDVVA
     SMVVFEDGLP RKSEYRRFII RGATDDLSAM SEVLRRRFAR YLDARAETGE AGVESAGDPA
     TPAGPASTGP GVPDEPRVGT LVDPTTGRPR KFAYPPQLVV VDGGAPQVAA AAQALAELGV
     DDVALCGLAK RLEEVWLPDD DFPAILPRTS EGLYLLQRVR DEAHRFAITF HRQRRSRRMT
     ESALDRVPGL GEVRRKALLR HFGSLKRLSA ASVEEITEVP GVGQRTAEAI LAALGDSTQP
     DEPRT