UVRC_SALTY
ID UVRC_SALTY Reviewed; 610 AA.
AC O66041;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 19-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=STM1946;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-608.
RC STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX PubMed=9495757; DOI=10.1128/jb.180.5.1185-1193.1998;
RA Ahmer B.M., van Reeuwijk J., Timmers C.D., Valentine P.J., Heffron F.;
RT "Salmonella typhimurium encodes an SdiA homolog, a putative quorum sensor
RT of the LuxR family, that regulates genes on the virulence plasmid.";
RL J. Bacteriol. 180:1185-1193(1998).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE006468; AAL20858.1; -; Genomic_DNA.
DR EMBL; U88651; AAC08301.1; -; Genomic_DNA.
DR RefSeq; NP_460899.1; NC_003197.2.
DR RefSeq; WP_001289461.1; NC_003197.2.
DR AlphaFoldDB; O66041; -.
DR SMR; O66041; -.
DR STRING; 99287.STM1946; -.
DR PaxDb; O66041; -.
DR EnsemblBacteria; AAL20858; AAL20858; STM1946.
DR GeneID; 1253467; -.
DR KEGG; stm:STM1946; -.
DR PATRIC; fig|99287.12.peg.2060; -.
DR HOGENOM; CLU_014841_3_0_6; -.
DR PhylomeDB; O66041; -.
DR BioCyc; SENT99287:STM1946-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.340; -; 1.
DR Gene3D; 3.40.1440.10; -; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_HhH_N; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; SSF46600; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF82771; SSF82771; 1.
DR TIGRFAMs; TIGR00194; uvrC; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW Reference proteome; SOS response.
FT CHAIN 1..610
FT /note="UvrABC system protein C"
FT /id="PRO_0000138334"
FT DOMAIN 16..94
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 204..239
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT CONFLICT 251
FT /note="D -> N (in Ref. 2; AAC08301)"
FT /evidence="ECO:0000305"
FT CONFLICT 279
FT /note="S -> T (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 281
FT /note="S -> T (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 381
FT /note="S -> T (in Ref. 2; AAC08301)"
FT /evidence="ECO:0000305"
FT CONFLICT 410
FT /note="A -> P (in Ref. 2; AAC08301)"
FT /evidence="ECO:0000305"
FT CONFLICT 455
FT /note="E -> K (in Ref. 2; AAC08301)"
FT /evidence="ECO:0000305"
FT CONFLICT 588
FT /note="E -> K (in Ref. 2; AAC08301)"
FT /evidence="ECO:0000305"
FT CONFLICT 602
FT /note="E -> K (in Ref. 2; AAC08301)"
FT /evidence="ECO:0000305"
FT CONFLICT 605..608
FT /note="FWSL -> RSRE (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 610 AA; 68034 MW; 003903F1C55EE0C7 CRC64;
MSEIFDAKAF LKTVTSQPGV YRMYDAGGTV IYVGKAKDLK KRLSSYFRSN LASRKTEALV
AQIQHIDVTV THTETEALLL EHNYIKLYQP RYNVLLRDDK SYPFIFLSGD THPRLAMHRG
AKHAKGEYFG PFPNGYAVRE TLALLQKIFP IRQCENSVYR NRSRPCLQYQ IGRCLGPCVA
GLVSEEEYAQ QVEYVRLFLS GKDDQVLTQL IARMEKASQD LAFEEAARIR DQIQAVRRVT
EKQFVSNAGD DLDVIGVAFD AGMACVHVLF IRQGKVLGSR SYFPKVPGGT ELGEVVETFV
GQFYLQGSQM RTLPGEILLD FNLSDKTLLA DSLSELAGRR IHVQTKPRGD RARYLKLART
NAATALITKL SQQSTITQRL SALAAVLKLP AIKRMECFDI SHTMGEQTVA SCVVFDANGP
LRAEYRRYNI AGITPGDDYA AMNQVLRRRY GKAIEESKIP DVILIDGGKG QLAQAKAVFA
ELDVPWDKHR PLLLGVAKGA DRKAGLETLF FEPEGEGFSL PPDSPALHVI QHIRDESHDH
AIGGHRKKRA KVKNTSTLET IEGVGPKRRQ MLLKYMGGLQ GLRNASVEEI AKVPGISQGL
AEKIFWSLKH
