ID   CAF20_DEBHA             Reviewed;         171 AA.
AC   Q6BLT5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Cap-associated protein CAF20;
GN   Name=CAF20; OrderedLocusNames=DEHA2F10868g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as an inhibitor of cap-dependent translation. Competes
CC       with eIF4G1 and EAP1 for binding to eIF4E and interferes with the
CC       formation of the eIF4F complex, inhibiting translation and stabilizing
CC       mRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CAF20 family. {ECO:0000305}.
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DR   EMBL; CR382138; CAG89181.1; -; Genomic_DNA.
DR   RefSeq; XP_460836.1; XM_460836.1.
DR   AlphaFoldDB; Q6BLT5; -.
DR   SMR; Q6BLT5; -.
DR   STRING; 4959.XP_460836.1; -.
DR   EnsemblFungi; CAG89181; CAG89181; DEHA2F10868g.
DR   GeneID; 2903571; -.
DR   KEGG; dha:DEHA2F10868g; -.
DR   VEuPathDB; FungiDB:DEHA2F10868g; -.
DR   eggNOG; ENOG502S2E7; Eukaryota.
DR   HOGENOM; CLU_128343_0_0_1; -.
DR   InParanoid; Q6BLT5; -.
DR   OMA; GHFNRRR; -.
DR   OrthoDB; 1474950at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005845; C:mRNA cap binding complex; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR031456; Caf20.
DR   Pfam; PF17052; CAF20; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis;
KW   Protein synthesis inhibitor; Reference proteome; Translation regulation.
FT   CHAIN           1..171
FT                   /note="Cap-associated protein CAF20"
FT                   /id="PRO_0000330086"
FT   REGION          49..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..101
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..129
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   171 AA;  19470 MW;  39E93A4F8FEA362C CRC64;
     MAKYTEEQLY EIKEEAYTPQ PDVLDAFNKM VDHVKEHAAA EFEKHKNLKW SNGDTYIDEN
     GNERPYHHMN KRRGSRSGNK PNLRKKSTDG IKVDDDGWAT LTKPKKSFGA EDGVEERNKF
     RESVKDIKVK PNNKNLGSSK AVDPRDAIAE KHTNTFNAFE ALGDGDDSDD E