ID   UVRC_SHEDO              Reviewed;         609 AA.
AC   Q12PA3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Sden_1437;
OS   Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=318161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OS217 / ATCC BAA-1090 / DSM 15013;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of Shewanella denitrificans OS217.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000302; ABE54723.1; -; Genomic_DNA.
DR   RefSeq; WP_011495881.1; NC_007954.1.
DR   AlphaFoldDB; Q12PA3; -.
DR   SMR; Q12PA3; -.
DR   STRING; 318161.Sden_1437; -.
DR   EnsemblBacteria; ABE54723; ABE54723; Sden_1437.
DR   KEGG; sdn:Sden_1437; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_6; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000001982; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..609
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264945"
FT   DOMAIN          15..93
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          202..237
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   609 AA;  68180 MW;  AC9B953D81E60EBA CRC64;
     MASFNATEFL KNLSSSAGVY RMYDAKGEVI YVGKAKDLKK RLSSYFRANL GNIKTQALVS
     HITNIDVTLT HSETDALLLE NDYIKQYMPK YNVLLRDDKS YPYLFLSGHK HPRLAYHRGP
     QREKGRYFGP YPNGGAVRES LNLLQKLFPI RQCDDLYYKA RTRPCLQYQL GRCSAPCVNK
     VTDEDYAEQV QLASLFLQGK DQQVVTNLVT KMEQAAEEFH YEQAAAYRDQ ITALRKVAEQ
     QEVSLDKGDM DVIGVHYEKA IACFHMLFIR SGKIFGSRSY YPSVPAQTDI DEVLSAFISQ
     FYLNADVQRT LPNEVILSQS FSDKAELESA IAEALEKKFI IKTQVRGERA SFLRLALTNA
     TNAVTTRLAD KNTQEQRFSL LEEALELGHS IGRMECFDIS HTMGESTVAS CVVFNREGPH
     KADYRRYNIS GITGGDDYAA MEQAINRRFD KIDTNGKVPD IVFIDGGLGQ LRIAQGIVDE
     KCAHLDRPPL LIGVTKGEGR KAGLETFVFG GSEQQFNLPS DSGAFHLILH IRDESHRFAI
     TGHRNKRQKT RNTSSLESIA GVGPKRRKAL LQHLGGLQEV KGASVAELTK VPGISLEMAQ
     TIHDALRGG