ID   UVRC_SODGM              Reviewed;         610 AA.
AC   Q2NTS9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=SG1171;
OS   Sodalis glossinidius (strain morsitans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Bruguierivoracaceae; Sodalis.
OX   NCBI_TaxID=343509;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=morsitans;
RX   PubMed=16365377; DOI=10.1101/gr.4106106;
RA   Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M.,
RA   Aksoy S.;
RT   "Massive genome erosion and functional adaptations provide insights into
RT   the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
RL   Genome Res. 16:149-156(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AP008232; BAE74446.1; -; Genomic_DNA.
DR   RefSeq; WP_011411002.1; NZ_LN854557.1.
DR   AlphaFoldDB; Q2NTS9; -.
DR   SMR; Q2NTS9; -.
DR   STRING; 343509.SG1171; -.
DR   PRIDE; Q2NTS9; -.
DR   EnsemblBacteria; BAE74446; BAE74446; SG1171.
DR   KEGG; sgl:SG1171; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_6; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   BioCyc; SGLO343509:SGP1_RS10275-MON; -.
DR   Proteomes; UP000001932; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..610
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264952"
FT   DOMAIN          16..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          204..239
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   610 AA;  68052 MW;  942D38D0E65DEA21 CRC64;
     MTDSFNAKQF LSTVTSQPGV YSMYDLSGTV IYVGKAKDLK KRLASYFRAQ VASRKTEALV
     KSIHHIDVTI THTETEALLL EHNYIKLYQP RYNVLLRDDK SYPFIFLSGD AHPRITSHRG
     AKHAKGDYFG PFPNGYAVKE TLALLQKLFP IRQCEDSVYR NRSRPCLQYQ IGRCLGPCVA
     GLVSDEEYQQ QVEYVRLFLS GKDQQVLNQL VERMELASRA LNFEDAAHAR DQIQAVRRVT
     EKQFVSGDRE DLDVIGVSFD AGMACVHVLF IRQGKVLGSR SYFPKVPVGT ELAEVVQTFV
     GQFYLQGSQM RSLPGEILLD FTLPEKTLLA ASLSEQAGRK IQIQTQPRGD RARYLKLART
     NAATALVTKL SQQSTVHQRL AALAELLGIQ AINRMECFDI SHTMGEHTIA SCVIFDGNGS
     VRAEYRRYNI EGITPGDDYA AMDQVLRRRY GKALEEKKIP DVVIIDGGKG QLGMAKAVFE
     QLEVPWDKSR VVLLGVAKGV DRKAGLETLF LQPHGEGMAL PPDSPALHVI QHIRDDSHNH
     AITGHRNKRA KVKNTSALEL IEGVGPRRRQ SLLKYMGGLQ PLRNASVEEI AQVPGISGAL
     AEKIFNALKH