ID   UVRC_STAAU              Reviewed;         593 AA.
AC   Q9ZEH3;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 9144 / DSM 683 / NCIB 6571 / NCTC 6571 / NRRL B-314 / Oxford;
RA   Uziel O., Borovok I., Schreiber R., Cohen G., Aharonowitz Y.;
RT   "Transcriptional analysis of the thioredoxin (trxA) and thioredoxin
RT   reductase (trxB) genes in Staphylococcus aureus.";
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AJ223480; CAA11405.1; -; Genomic_DNA.
DR   RefSeq; WP_000390514.1; NZ_WKIW01000014.1.
DR   AlphaFoldDB; Q9ZEH3; -.
DR   SMR; Q9ZEH3; -.
DR   OMA; HIECFDN; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..593
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138341"
FT   DOMAIN          17..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          199..234
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   593 AA;  68644 MW;  3653D07314A59D11 CRC64;
     MEDYKKRIKN KLNVVPMEPG CYLMKDRNDQ VIYVGKAKKL RNRLRSYFTG AHDAKTTRLV
     GEIRRFEFIV TSSETESLLL ELNLIKQYQP RYNILLKDDK SYPFIKITKE KYPRLLVTRT
     VKQGTGKYFG PYPNAYSAQE TKKLLDRIYP YRKCDKMPDK LCLYYHIGQC LGPCVYDVDL
     SKYAQMTKEI TDFLNGEDKT ILKSLEERML TASESLDFER AKEYRDLIQH IQNLTNKQKI
     MSSDKTIRDV FGYSVDKGWM CIQVFFIRQG NMIKRDTTMI PLQQTEEEEF YTFIGQFYSL
     NQHILPKEVH VPRNLDKEMI QSVVDTKIVQ PARGPKKDMV DLAAHNAKVS LNNKFELISR
     DESRTIKAIE ELGTQMGIQT PIRIEAFDNS NIQGVDPVSA MVTFVDGKPD KKNYRKYKIK
     TVKGPDDYKS MREVVRRRYS RVLNEGLPLP DLIIVDGGKG HMNGVIDVLQ NELGLDIPVA
     GLQKNDKHQT SELLYGASAE IVPLKKNSQA FYLLHRIQDE VHRFAITFHR QTRQKTGLKS
     ILDDIDGIGS KRKTLLLRSF GSIKKMKEAT LEDFKNIGIP ENVAKNLHEQ LHK