UVRC_STAS1
ID UVRC_STAS1 Reviewed; 595 AA.
AC Q49WR3;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=SSP1649;
OS Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS 20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=342451;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT pathogenesis of uncomplicated urinary tract infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; AP008934; BAE18794.1; -; Genomic_DNA.
DR RefSeq; WP_011303382.1; NZ_MTGA01000039.1.
DR AlphaFoldDB; Q49WR3; -.
DR SMR; Q49WR3; -.
DR STRING; 342451.SSP1649; -.
DR EnsemblBacteria; BAE18794; BAE18794; SSP1649.
DR KEGG; ssp:SSP1649; -.
DR PATRIC; fig|342451.11.peg.1648; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_3_2_9; -.
DR OMA; HIECFDN; -.
DR OrthoDB; 1036075at2; -.
DR Proteomes; UP000006371; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.340; -; 1.
DR Gene3D; 3.40.1440.10; -; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_HhH_N; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; SSF46600; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF82771; SSF82771; 1.
DR TIGRFAMs; TIGR00194; uvrC; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW Reference proteome; SOS response.
FT CHAIN 1..595
FT /note="UvrABC system protein C"
FT /id="PRO_0000227475"
FT DOMAIN 17..94
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 199..234
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ SEQUENCE 595 AA; 68653 MW; 7B2DD74B5292AD2D CRC64;
METYQEKIKQ KLTVVPIEPG CYLMKDRNDQ IIYVGKAKKL RNRLRSYFTG AHDAKTTRLV
GEIRNFEFIV TSSETESLLL ELNLIKQYQP RYNILLKDDK SYPFIKITKE KYPRLIVTRT
VKKGSGKYFG PYPNAYSAQE TKKLLDRIYP FRKCDKMPDK LCLYYHIGQC LGPCVYPVDL
EKYAEMTKEI TDFLNGEDKT ILHNLEQKMQ ESSESLDFER AKEYRDLIQH IHNLNKKQKI
TSSDNTIRDV FGYSISKGWM CIQVFFIRQG NMIKRDATMI PLQQTEEEEF YTFIGQFYDL
NQHILPKEVH VPKHLNKELI QSVVDTKIVQ PLKGKKKDMV DLANHNAEVT LENKFELIAK
DESRTVKAIE ELGDVMGIQT PIRIEAFDNS NIQGVNPVSA MVSFIDGKPN KKGYRKYKIK
TVDGPDDYKS MREVVRRRYT RVLNEGSPLP DLIIVDGGKG HMSGVIDVLE NELGLDIPVA
GLRKNDKHQT SEILYGEQAE VVPMKKNSQP FYLLQRIQDE VHRFAITFHR QTRQKTGLQS
VLDTVDGIGA KRKTKLLRTF GSIKRMKEAS VEDLKNSGLP QNVAENLHHA LSNNS