ID   CAF20_PICST             Reviewed;         178 AA.
AC   A3LQ93;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Cap-associated protein CAF20;
GN   Name=CAF20; ORFNames=PICST_88036;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Acts as an inhibitor of cap-dependent translation. Competes
CC       with eIF4G1 and EAP1 for binding to eIF4E and interferes with the
CC       formation of the eIF4F complex, inhibiting translation and stabilizing
CC       mRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CAF20 family. {ECO:0000305}.
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DR   EMBL; CP000496; ABN65168.1; -; Genomic_DNA.
DR   RefSeq; XP_001383197.1; XM_001383160.1.
DR   AlphaFoldDB; A3LQ93; -.
DR   SMR; A3LQ93; -.
DR   STRING; 4924.XP_001383197.1; -.
DR   PRIDE; A3LQ93; -.
DR   EnsemblFungi; ABN65168; ABN65168; PICST_88036.
DR   GeneID; 4837250; -.
DR   KEGG; pic:PICST_88036; -.
DR   eggNOG; ENOG502S2E7; Eukaryota.
DR   HOGENOM; CLU_128343_0_0_1; -.
DR   InParanoid; A3LQ93; -.
DR   OMA; GHFNRRR; -.
DR   OrthoDB; 1474950at2759; -.
DR   Proteomes; UP000002258; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005845; C:mRNA cap binding complex; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR031456; Caf20.
DR   Pfam; PF17052; CAF20; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis;
KW   Protein synthesis inhibitor; Reference proteome; Translation regulation.
FT   CHAIN           1..178
FT                   /note="Cap-associated protein CAF20"
FT                   /id="PRO_0000330090"
FT   REGION          61..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..99
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..122
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   178 AA;  20057 MW;  CE00ED039A4279EC CRC64;
     MVKYTEDRLL ELKEETYIPQ PQILEAFNQM IESVKEHAAA EAEKHKAIKW NNGDTYIDEH
     GNERPYHHMN RRRASRTANK PSLRKKSVEN VDEDGWATLS KPKRSFGADE GLEERAKFRE
     SVREGTVGGS GTVKAKPNNK NLGSSKAVDP RDAIADKHTT TFNAFEALGD GDDDDDDE