ID   UVRC_STRCO              Reviewed;         728 AA.
AC   Q9Z512;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 133.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=SCO1953;
GN   ORFNames=SCC54.13c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AL939110; CAB38143.1; -; Genomic_DNA.
DR   PIR; T36026; T36026.
DR   RefSeq; NP_626217.1; NC_003888.3.
DR   RefSeq; WP_011028063.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; Q9Z512; -.
DR   SMR; Q9Z512; -.
DR   STRING; 100226.SCO1953; -.
DR   GeneID; 1097387; -.
DR   KEGG; sco:SCO1953; -.
DR   PATRIC; fig|100226.15.peg.1979; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_1_1_11; -.
DR   InParanoid; Q9Z512; -.
DR   OMA; HIECFDN; -.
DR   PhylomeDB; Q9Z512; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..728
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138345"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          473..535
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          689..728
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   728 AA;  80841 MW;  6DFDD3439BEBADD6 CRC64;
     MADPSSYRPR PGEIPDSPGV YRFRDEHRRV IYVGKAKSLR QRLANYFQDL AHLHPRTRTM
     VTTAASVEWT VVSTEVEALQ LEYSWIKEYD PRFNVKYRDD KSYPYLAVTM NEEFPRVQVM
     RGQKKKGVRY FGPYGHAWAI RDTVDLLLRV FPVRTCSAGV FKNAARTGRP CLLGYIGKCS
     APCVGRITPD DHWDLADEFC DFMAGRTGTY LRRLERQMAE AAEEMEYERA ARLRDDIGAL
     KKAMEKSAVV LADATDADLI AVAEDELEAA VQIFHVRGGR VRGQRGWVTD KVEEITTGAL
     VEHALQQLYG EEKGDAVPKE VLVPALPDPV EPVQQWLAER RGSGVSLRIP QRGDKKALME
     TVQRNAQQAL VLHKTKRASD LTTRSRALEE IAEALDLDSA PLRIECYDIS HLQGDDVVAS
     MVVFEDGLAR KSEYRRFQIK GFEGQDDVRS MHEVITRRFR RYLAEKERTG EWADGEGLVD
     DARHPNGDAA PNGDAAPNDG AAPDDGAART DGRGLTDGQE LTDGPALKDD DGRPKRFAYP
     PQLVVVDGGQ PQVAAAQRAL DELGIDDIAV CGLAKRLEEV WLPREDDPVV LPRTSEGLYL
     LQRVRDEAHR FAITYQRAKR AKRFRAGPLD DVPGLGETRK QALIKHFGSV KKLRSATIDQ
     ICEVPGIGRK TAETVAVALA RATPAAPAVN TATGEIMDDD DGAPETTADA PGEPVSAGTP
     DERRGQER