ID   UVRC_STRGG              Reviewed;         717 AA.
AC   B1W0Y8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=SGR_5569;
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350;
RX   PubMed=18375553; DOI=10.1128/jb.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT   griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AP009493; BAG22398.1; -; Genomic_DNA.
DR   RefSeq; WP_012381399.1; NC_010572.1.
DR   AlphaFoldDB; B1W0Y8; -.
DR   SMR; B1W0Y8; -.
DR   STRING; 455632.SGR_5569; -.
DR   EnsemblBacteria; BAG22398; BAG22398; SGR_5569.
DR   GeneID; 6210068; -.
DR   KEGG; sgr:SGR_5569; -.
DR   PATRIC; fig|455632.4.peg.5704; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_1_1_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..717
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000099521"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          467..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        533..548
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   717 AA;  78994 MW;  0CD0675236612351 CRC64;
     MADPSSYRPK PGQIPDSPGV YKFRDEHRRV IYVGKAKNLR QRVANYFQDL ANLHPRTRTM
     VTTAASVEWT VVSTEVEALQ LEYSWIKEFD PRFNVKYRDD KSYPYLAVTL NEEFPRVQVM
     RGAKKKGVRY FGPYGHAWAI RETVDLMLRV FPVRTCSAGV FKNAARTGRP CLLGYIGKCS
     APCVGRVTPE EHRELAEDFC DFMAGRTGTY IRRLEKDMMQ AAEEMEYERA ARLRDDAEAL
     KRAMEKSAVV LADATDADLI AVAEDELEAA LQIFHVRGGR VRGQRGWVTD KVEAVDTSGL
     VEHALQQLYG EERGDAVPKE VLVPALPEDP EAVSQWLADR RGSQVSLRIP QRGDKKDLMA
     TVQRNAQQAL GLHKTKRASD LTTRSRALEE IAEALGLDTA PLRIECYDIS HLQGDDVVAS
     MVVFEDGLAR KSEYRRFQIK GFEGQDDVRS MHEVIGRRFK RYLQDKERTG EWEEAPEAAP
     GSASVHASAT GPAATGQATA GPAAMGQAAA GPVSTGPAAT GPVPAPELTA ASPDDEPEPR
     EDDGRPKRFA YPPQLVVVDG GQPQVAAARR ALDELGIDDI AVCGLAKRLE EVWLPDDDDP
     VVLPRSSEGL YLLQRVRDEA HRFAITYQRA KRAKRIRSSP LDDVTGLGET RKQALIKHFG
     SVKKLRQATI DEICEVPGIG RRTAESVVAA LATTAPAAPA VNTATGEIIE EDDGGSS